X0306 4 2021-11-12 0 0001637715 Reneo Pharmaceuticals, Inc. RPHM 0001801842 Hall Ashley C/O RENEO PHARMACEUTICALS, INC. 18575 JAMBOREE ROAD, SUITE 275-S IRVINE CA 92612 0 1 0 0 Chief Development Officer Common Stock 2021-11-12 4 A 0 30000 0.00 A 30000 D Stock Option (right to buy) 8.85 2021-11-12 4 A 0 180000 0.00 A 2031-11-11 Common Stock 180000 180000 D Represents a restricted stock unit award. 1/4 of the shares subject to the stock option vest and become exercisable on October 11, 2022, and the remaining shares vest in equal monthly installments over the subsequent 36 months. /s/ Vineet R. Jindal, Attorney-in-Fact 2021-11-15