Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Cash flows from operating activities:
Net loss	$ (59,517)	$ (52,673)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation expense	11,633	4,530
Depreciation and amortization	447	459
Amortization of right-of-use asset - operating	383	203
Loss on disposal of property and equipment	6
Amortization of debt issuance costs		142
Non-cash interest expense		120
Loss on sales of available-for-sale securities		54
Change in operating assets and liabilities:
Prepaid and other assets	289	2,256
Accounts payable, accrued and other liabilities	(4,545)	(5,927)
Lease liabilities	(536)	(281)
Other long-term liabilities	12
Net cash used in operating activities	(51,828)	(51,117)
Cash flows from investing activities:
Proceeds from sales of marketable securities		15,925
Purchases of property and equipment	(46)	(52)
Net cash (used in) provided by investing activities	(46)	15,873
Cash flows from financing activities:
Cash acquired in connection with the reverse recapitalization		57,736
Payment of reverse recapitalization transaction costs	(40)	(2,045)
Proceeds from issuance of convertible notes payable		6,000
Payment of issuance costs associated with the issuance of convertible notes payable		(142)
Proceeds from sale of stock under the employee stock purchase plan	240
Proceeds from the issuance of common stock for exercises of stock options		26
Net cash provided by financing activities	163	116,129
Net decrease in cash and cash equivalents	(51,711)	80,885
Cash and cash equivalents, beginning of period	110,761	29,876
Cash and cash equivalents, end of period	59,050	110,761
Supplemental disclosure of noncash investing activities:
Conversion of Series C Preferred Stock		129,825
Conversion of convertible note payable		6,120
Assets acquired in connection with the reverse recapitalization		17,222
Other liabilities assumed in connection with the reverse recapitalization		9,459
Reverse recapitalization transaction costs included in accounts payable		40
Concurrent Financing issuance costs included in accounts payable		37
Concurrent Financing issuance costs paid by Reneo prior to Merger		89
Private Placement
Cash flows from financing activities:
Proceeds from the issuance of common stock in Concurrent Financing		58,881
Payment of issuance costs associated with the Concurrent Financing	$ (37)	$ (4,327)