144 0002038798 XXXXXXXX LIVE 0001636282 SPYRE THERAPEUTICS INC 001-37722 221 Crescent Street Building 23 Waltham MA 02453 617-651-5940 SHELDON SLOAN Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

16667 1152689.72 86841253 06/03/2026 NASDAQ Common 06/03/2026 Exercise of Stock Options Issuer N 16667 06/03/2026 Cash N 10b5-1 Sales for SHELDON SLOAN

221 Crescent Street Building 23 Waltham MA 02453

Common 05/01/2026 78333 5600884.57 10b5-1 Sales for SHELDON SLOAN

221 Crescent Street Building 23 Waltham MA 02453

Common 04/01/2026 7958 397900.00 The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 06/03/2026 06/20/2025 /s/ Sheldon Sloan