144 0002038798 XXXXXXXX LIVE 0001636282 SPYRE THERAPEUTICS INC 001-37722 221 Crescent Street Building 23 Suite 105 Waltham MA 02453 617-651-5940 SHELDON SLOAN Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

7958 401401.52 78540164 04/01/2026 NASDAQ Common 04/01/2026 Exercise of Stock Options Issuer N 7958 04/01/2026 Cash Y 04/01/2026 06/20/2025 /s/ Sheldon Sloan