144 0001853327 XXXXXXXX LIVE 0001636282 SPYRE THERAPEUTICS INC 001-37722 221 Crescent Street Building 23 Waltham MA 02453 617-651-5940 SCOTT BURROWS Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

10000 424900.00 78540164 03/03/2026 NASDAQ Common 03/03/2026 Exercise of Stock Options Issuer N 10000 03/03/2026 Cash Y The securities to be sold were and will be received upon the exercise of stock options over the next three months. The dates of acquisition and payment were and will be the dates of exercise/sale. 03/03/2026 11/10/2025 /s/ Scott Burrows