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Preferred stock remains issued and outstanding percentage. 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Accrued and other current liabilities Total accrued and other current liabilities Accrued Liabilities and Other Liabilities October 2025 Underwritten Offering October 2025 Underwritten Offering [Member] October 2025 Underwritten Offering Entity Address, City or Town Entity Address, City or Town CASH FLOWS FROM OPERATING ACTIVITIES Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract] Other segment items Segment Reporting, Other Segment Item, Amount Sale of stock, authorized amount Sale of Stock, Authorized Amount Sale of Stock, Authorized Amount Accrued contracted research and development costs Accrued Contracted Research And Development Costs Accrued contracted research and development costs. Non-PEO NEO Average Compensation Actually Paid Amount Non-PEO NEO Average Compensation Actually Paid Amount Statement of Income Location, Balance [Domain] Statement of Income Location, Balance [Domain] Restricted Stock Units (RSUs) Unvested restricted stock units Restricted Stock Units (RSUs) [Member] CASH AND CASH EQUIVALENTS Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Including Discontinued Operation [Abstract] Compensation Actually Paid vs. Other Measure Compensation Actually Paid vs. Other Measure [Text Block] Financial Assets: Assets, Fair Value Disclosure [Abstract] Spyre Therapeutics, Inc. Spyre Therapeutics, Inc. [Member] Spyre Therapeutics, Inc. 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Plan Name [Axis] Plan Name [Axis] PEO PEO [Member] Schedule of Contractual Maturities of Marketable Securities at Estimated Fair Value Investments Classified by Contractual Maturity Date [Table Text Block] Supplemental Disclosure of Non-Cash Financing Information: Noncash Investing and Financing Items [Abstract] Changes in operating assets and liabilities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year Dividends or Other Earnings Paid on Equity Awards not Otherwise Reflected in Total Compensation for Covered Year [Member] Due in 1 - 2 years Debt Securities, Available-For-Sale, Fair Value, Maturity, Allocated And Single Maturity Date, After Year One Debt Securities, Available-For-Sale, Fair Value, Maturity, Allocated And Single Maturity Date, After Year One Expected volatility Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate Accumulated Deficit Retained Earnings [Member] Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Schedule of Accrued and Other Current Liabilities Schedule of Accrued Liabilities [Table Text Block] Entity Address, Postal Zip Code Entity Address, Postal Zip Code Restatement Determination Date Restatement Determination Date Share-Based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Beginning of period End of period Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Income Statement [Abstract] Income Statement [Abstract] Income tax benefit Income Tax Expense (Benefit) 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Sale of Stock [Domain] Sale of Stock [Domain] Non-current CVR liability Derivative Liability, Noncurrent Preferred stock, issued (in shares) Preferred Stock, Shares Issued Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Fair Value Hierarchy and NAV [Axis] Fair Value Hierarchy and NAV [Axis] Cash, cash equivalents, and marketable securities Cash, Cash Equivalents, and Short-Term Investments Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Total liabilities Liabilities, Fair Value Disclosure Discontinued Operations and Disposal Groups [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] City Area Code City Area Code Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] All Trading Arrangements All Trading Arrangements [Member] Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] April 2026 Underwriting Agreement April 2026 Underwriting Offering [Member] April 2026 Underwriting Offering CASH FLOWS FROM INVESTING ACTIVITIES Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract] General and administrative General and Administrative Expense Campaign timeline, minimum term (in years) Campaign Timeline, Minimum Term Campaign Timeline, Minimum Term Pay vs Performance Disclosure Pay vs Performance Disclosure [Table] Net cash used in operating activities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Accrued interest receivable on available-for-sale debt securities Interest Receivable Disposal Group, Disposed of by Sale, Not Discontinued Operations Disposal Group, Disposed of by Sale, Not Discontinued Operations [Member] Related Party Transactions [Abstract] Related Party Transactions [Abstract] Preferred stock, par value (in dollars per share) Preferred Stock, Par or Stated Value Per Share Schedule of Weighted-Average Assumptions Used in Calculating Fair Value of Awards Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] Subsequent Events Subsequent Event [Member] First milestone payment Payment Of Milestone Payment of milestone. Proceeds from stock option exercises received in subsequent period Noncash Stock Options Exercised In Subsequent Period Noncash Stock Options Exercised In Subsequent Period Equity Valuation Assumption Difference, Footnote Equity Valuation Assumption Difference, Footnote [Text Block] PEO Total Compensation Amount PEO Total Compensation Amount Money market funds Money market funds Money Market Funds [Member] Derivative liability, measurement input Derivative Liability, Measurement Input Denominator Weighted Average Number of Shares Outstanding, Basic [Abstract] Series B Non Voting Convertible Preferred Stock Series B Non-Voting Convertible Preferred Stock Series B Preferred Stock Series B Non Voting Convertible Preferred Stock [Member] Series B Non Voting Convertible Preferred Stock Equity Components [Axis] Equity Components [Axis] Non-Rule 10b5-1 Arrangement Adopted Non-Rule 10b5-1 Arrangement Adopted [Flag] Number of reportable segments Number of Reportable Segments Number of board seats held by related party Related Party Transaction, Number Of Board Seats Related Party Transaction, Number Of Board Seats Sale of stock, aggregate offering price Sale of Stock, Aggregate Offering Price Sale of Stock, Aggregate Offering Price Proceeds from issuance of common stock in connection with at-the-market offering program, net of issuance costs Proceeds From Issuance of Common Stock, At-The-Market Offerings, Net Proceeds From Issuance of Common Stock, At-The-Market Offerings, Net Appoint Of Board Members Appoint Of Board Members [Member] Appoint Of Board Members Marketable securities, amortized cost Debt Securities, Available-for-Sale, Amortized Cost Other Performance Measure, Amount Other Performance Measure, Amount Foreign currency translation adjustment Foreign currency translation adjustment Other Comprehensive Income (Loss), Foreign Currency Transaction and Translation Gain (Loss) Arising During Period, Net of Tax Entity Address, State or Province Entity Address, State or Province Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table] Antidilutive Security, Excluded EPS Calculation [Table] Interest proceeds from maturities of zero coupon U.S. Treasury Bills Interest Proceeds, Debt Securities Interest Proceeds, Debt Securities Related and Nonrelated Parties [Domain] Related and Nonrelated Parties [Domain] Total current liabilities Liabilities, Current Royalty term expiration period (in years) Royalty Term, Expiration Period Royalty Term, Expiration Period Over-Allotment Option Over-Allotment Option [Member] Derivative Instrument [Axis] Derivative Instrument [Axis] Individual: Individual [Axis] Vesting [Axis] Vesting [Axis] Net loss per share, basic and diluted: Earnings Per Share Reconciliation [Abstract] Consulting Agreement Consulting Agreement [Member] Consulting Agreement Contingent consideration Disposal Group, Including Discontinued Operation, Contingent Consideration Disposal Group, Including Discontinued Operation, Contingent Consideration Research and development Research and Development Expense [Member] Additional paid-in capital Additional Paid in Capital, Common Stock Net cash provided by (used in) investing activities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table Aggregate Change in Present Value of Accumulated Benefit for All Pension Plans Reported in Summary Compensation Table [Member] Document Fiscal Year Focus Document Fiscal Year Focus Basis of Presentation Basis of Accounting, Policy [Policy Text Block] Forgone Recovery, Explanation of Impracticability Forgone Recovery, Explanation of Impracticability [Text Block] Percentage of ownership by noncontrolling owner Subsidiary, Ownership Percentage, Noncontrolling Owner Issuance of common stock in connection with exercise of stock options and employee stock purchase plan (in shares) Stock Issued During Period, Shares, Options Exercised And Employee Stock Ownership Plan Stock Issued During Period, Shares, Options Exercised And Employee Stock Ownership Plan Entity Interactive Data Current Entity Interactive Data Current Plan Name [Domain] Plan Name [Domain] Cash Equivalents And Marketable Securities [Line Items] Cash Equivalents And Marketable Securities [Line Items] Cash equivalents and marketable securities. Royalty step-down (as percent) Royalty Step-Down, Percent Royalty Step-Down, Percent Equity [Abstract] Equity [Abstract] Acquired in-process research and development Acquired In Process Research And Development Acquired in process research and development Segment Reporting Segment Reporting Disclosure [Text Block] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] U.S. government treasury securities U.S. government treasury securities U.S. government treasury securities US Treasury Securities [Member] Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity [Roll Forward] Fair Value Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss [Abstract] Ownership [Domain] Ownership [Domain] Compensation Actually Paid vs. Total Shareholder Return Compensation Actually Paid vs. Total Shareholder Return [Text Block] Fair Value, Recurring and Nonrecurring [Table] Fair Value, Recurring and Nonrecurring [Table] Payment for sublicensing fee Payment For Sublicensing Fee Payment For Sublicensing Fee Entity Central Index Key Entity Central Index Key PEO Name PEO Name Sale of stock, proceeds received Sale of Stock, Consideration Received on Transaction Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year Prior Year End Fair Value of Equity Awards Granted in Any Prior Year that Fail to Meet Applicable Vesting Conditions During Covered Year [Member] Outstanding Aggregate Erroneous Compensation Amount Outstanding Aggregate Erroneous Compensation Amount Beginning balance Ending balance Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability Value Arrangement Duration Trading Arrangement Duration Share-Based Payment Arrangement, Tranche One Share-Based Payment Arrangement, Tranche One [Member] Segments [Axis] Segments [Axis] Exercise price per warrant (in dollars per share) Class of Warrant or Right, Exercise Price of Warrants or Rights Prepaid expenses and other assets Increase (Decrease) in Prepaid Expense and Other Assets Exercise Price Award Exercise Price Entity Filer Category Entity Filer Category Class of Stock [Domain] Class of Stock [Domain] Local Phone Number Local Phone Number Additional 402(v) Disclosure Additional 402(v) Disclosure [Text Block] Stock-Based Compensation Share-Based Payment Arrangement [Text Block] Subsequent Event Type [Axis] Subsequent Event Type [Axis] Receivable outstanding Disposal Group, Including Discontinued Operation, Consideration 2015 and 2016 and 2018 Equity Inducement Plan Two Thousand And Fifteen And Two Thousand And Sixteen Equity Incentive Plan And Two Thousand And Eighteen Equity Inducement Plan [Member] Two thousand and fifteen and two thousand and sixteen equity incentive plan and two thousand and eighteen equity inducement plan. ASSETS Assets [Abstract] Nonrelated Party Nonrelated Party [Member] Underlying Security Market Price Change Underlying Security Market Price Change, Percent Class of Warrant or Right [Domain] Class of Warrant or Right [Domain] Entity Address, Address Line Three Entity Address, Address Line Three Vesting [Domain] Vesting [Domain] Annual percentage of additional shares Annual Percentage Of Additional Shares Which Equals To Issued And Outstanding Shares Annual percentage of additional shares which equals to the issued and outstanding shares. Fair Value Measurements Fair Value Disclosures [Text Block] STOCKHOLDERS’ EQUITY Equity, Attributable to Parent [Abstract] CVR liability Derivative Liability, Current Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Vesting percentage Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage Entity Address, Address Line One Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Two Research and development, excluding compensation and share-based compensation Research and Development Expense Michael Henderson [Member] Michael Henderson Accumulated Other Comprehensive Income AOCI Attributable to Parent [Member] Termination notice period (in days) Termination Notice Period Termination Notice Period Accrued and other liabilities Increase (Decrease) in Accrued Liabilities and Other Operating Liabilities Series A Non Voting Convertible Preferred Stock Series A Non-Voting Convertible Preferred Stock Series A Preferred Stock Series A Non Voting Convertible Preferred Stock [Member] Series A non voting convertible preferred stock. Ownership [Axis] Ownership [Axis] Convertible Preferred Stock and Stockholders' Equity Preferred Stock [Text Block] Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items] Fair Value as of Grant Date Award Grant Date Fair Value Entity Registrant Name Entity Registrant Name Compensation Compensation Expense, Excluding Cost of Good and Service Sold Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Milestone payments, outstanding and payable License Agreement, Milestone Payments Outstanding and Payable License Agreement, Milestone Payments Outstanding and Payable At-The-Market Offering At-The-Market Offering [Member] At-The-Market Offering Restricted stock units, Grants (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period Related Party Transaction [Line Items] Related Party Transaction [Line Items] Document Quarterly Report Document Quarterly Report Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Total financial assets Assets, Fair Value Disclosure Schedule of Significant Inputs Used to Estimate the Fair Value of CVR Liability Fair Value Measurement Inputs and Valuation Techniques [Table Text Block] Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Number of operating segments Number of Operating Segments Net accretion of discount on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Adjustment To PEO Compensation, Footnote Adjustment To PEO Compensation, Footnote [Text Block] Restricted stock units, Weighted Average Grant Date Fair Value (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value Related and Nonrelated Parties [Axis] Related and Nonrelated Parties [Axis] Title Trading Arrangement, Individual Title Peer Group Total Shareholder Return Amount Peer Group Total Shareholder Return Amount Restatement Determination Date: Restatement Determination Date [Axis] Stock-based compensation expense Shares Issued, Value, Share-Based Payment Arrangement, after Forfeiture Non-PEO NEO Non-PEO NEO [Member] Sale of Stock [Axis] Sale of Stock [Axis] Marketable securities, gross unrealized gains Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax Name Trading Arrangement, Individual Name Award Type [Domain] Award Type [Domain] Cash Equivalents And Marketable Securities [Table] Cash Equivalents And Marketable Securities [Table] Cash equivalents and marketable securities. Equity Awards Adjustments Equity Awards Adjustments [Member] Pension Benefits Adjustments, Footnote Pension Benefits Adjustments, Footnote [Text Block] Compensation Amount Outstanding Recovery Compensation Amount Dividend yield Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate Statement of Comprehensive Income [Abstract] Statement of Comprehensive Income [Abstract] Recovery of Erroneously Awarded Compensation Disclosure [Line Items] Allocation of deferred offering costs against proceeds of issuance of common stock Deferred Offering Costs, Allocated Amount of Proceeds of Issuance of Common Stock Deferred Offering Costs, Allocated Amount of Proceeds of Issuance of Common Stock Preferred Stock Preferred Stock [Member] MNPI Disclosure Timed for Compensation Value MNPI Disclosure Timed for Compensation Value [Flag] 2016 ESPP 2016 ESPP [Member] 2016 ESPP Name Awards Close in Time to MNPI Disclosures, Individual Name Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] Segment, Reconciliation of Other Items from Segments to Consolidated [Line Items] Aggregate Erroneous Compensation Not Yet Determined Aggregate Erroneous Compensation Not Yet Determined [Text Block] Employee Stock Employee Stock [Member] Money market funds Cash equivalents, amortized cost Cash Equivalents, at Carrying Value Schedule of Stock Awards Granted Under all Equity Incentive and Inducement Plans Schedule of Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Grant Date Intrinsic Value [Table Text Block] Paragon Therapeutics Inc Paragon Therapeutics Inc [Member] Paragon therapeutics, Inc. Accumulated other comprehensive (loss) income Accumulated Other Comprehensive Income (Loss), Net of Tax Number of domestic banking institutions (in banks) Number Of Domestic Banking Institutions Number Of Domestic Banking Institutions Financial Instruments [Domain] Financial Instruments [Domain] Segments [Domain] Segments [Domain] Statement of Income Location, Balance [Axis] Statement of Income Location, Balance [Axis] Sublicensing fee, outstanding and payable Sublicensing Fee, Outstanding And Payable Sublicensing Fee, Outstanding And Payable Aggregate Pension Adjustments Service Cost Aggregate Pension Adjustments Service Cost [Member] Sublicensing fee Sublicensing Fee Sublicensing Fee Fair Value Hierarchy and NAV [Domain] Fair Value Hierarchy and NAV [Domain] Commercial paper Commercial Paper, Not Included with Cash and Cash Equivalents [Member] Warrants to purchase shares (in shares) Class of Warrant or Right, Number of Securities Called by Warrants or Rights Minimum Minimum [Member] Number of monthly installments Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Monthly Installments Share-Based Compensation Arrangement By Share-Based Payment Award, Number Of Monthly Installments Net Loss Per Share Earnings Per Share, Policy [Policy Text Block] Company Selected Measure Name Company Selected Measure Name Purchases of marketable securities Payments to Acquire Debt Securities, Available-for-Sale Preferred stock Preferred Stock, Value, Issued Aggregate Available Trading Arrangement, Securities Aggregate Available Amount Accounts payable Accounts Payable, Current Stock Appreciation Rights (SARs) Stock Appreciation Rights (SARs) [Member] Cash, FDIC insured amount (up to) Cash, FDIC Insured Amount All Executive Categories All Executive Categories [Member] Common stock, $0.0001 par value; 400,000,000 shares authorized as of March 31, 2026 and December 31, 2025; 78,839,858 shares and 78,189,811 shares issued and outstanding as of March 31, 2026 and December 31, 2025, respectively. Common Stock, Value, Issued Sale of stock, remaining authorized amount Sale of Stock, Remaining Authorized Amount Sale of Stock, Remaining Authorized Amount Weighted-average common stock outstanding, diluted (in shares) Weighted Average Number of Shares Outstanding, Diluted Commitments and Contingencies (Notes 6 and 7) Commitments and Contingencies Non-GAAP Measure Description Non-GAAP Measure Description [Text Block] Entity Small Business Entity Small Business Placement agent and other offering costs Payments of Stock Issuance Costs Percentage of ownership held in third party Minority Interest Ownership Percentage By Noncontrolling Owners Held In Third Party Minority interest ownership percentage by noncontrolling owners held in third party. U.S. Banking Institution U.S. Banking Institution [Member] U.S. Banking Institution [Member] Preferred stock, outstanding (in shares) Beginning balance, preferred stock (in shares) Ending balance, preferred stock (in shares) Preferred Stock, Shares Outstanding Document Transition Report Document Transition Report Numerator Net Income (Loss) Available to Common Stockholders, Basic [Abstract] Underlying Securities Award Underlying Securities Amount License Agreement Paragon Agreement, License Milestone Payments [Member] Paragon Agreement, License Milestone Payments Subsequent to Asset Acquisition Paragon Agreement, Subsequent to Asset Acquisition [Member] Paragon Agreement, Subsequent to Asset Acquisition Equity Component [Domain] Equity Component [Domain] Document Period End Date Document Period End Date PEO Actually Paid Compensation Amount PEO Actually Paid Compensation Amount Cash equivalents, gross unrealized gains Cash Equivalents Unrealized Gains Cash equivalents unrealized gains. Cash and Cash Equivalents [Domain] Cash and Cash Equivalents [Domain] Cash Equivalents and Marketable Securities Cash, Cash Equivalent, and Marketable Security [Text Block] Awards Close in Time to MNPI Disclosures, Table Awards Close in Time to MNPI Disclosures [Table Text Block] SPY001 License Agreement SPY001 License Agreement [Member] SPY001 License Agreement. Document Type Document Type Unrealized Losses Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] Level 3 Fair Value, Inputs, Level 3 [Member] Net Loss Per Share Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Related party accounts payable Accounts Payable and Other Accrued Liabilities, Current Derivative Contract [Domain] Derivative Contract [Domain] Asset Acquisition [Domain] Asset Acquisition [Domain] Asset acquisition, cash payment, threshold period (in years) Asset Acquisition, Cash Payment, Threshold Period Asset Acquisition, Cash Payment, Threshold Period All Individuals All Individuals [Member] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Name Forgone Recovery, Individual Name Expiration term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period Total current assets Assets, Current Statistical Measurement [Axis] Statistical Measurement [Axis] Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Disposal Group Classification [Axis] Disposal Group Classification [Axis] Proceeds from employee stock option exercises and employee stock plan purchases Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Including Option Exercised Weighted-average shares outstanding (in shares) Weighted Average Number of Shares Issued, Basic Aggregate Erroneous Compensation Amount Aggregate Erroneous Compensation Amount Disposal Group Name [Axis] Disposal Group Name [Axis] Impairment of marketable securities Impairment Of Marketable Securities Impairment of marketable securities. Peer Group Issuers, Footnote Peer Group Issuers, Footnote [Text Block] Payment of deferred offering costs in connection with shelf registration Payment For Deferred Offering Costs Payment For Deferred Offering Costs Erroneous Compensation Analysis Erroneous Compensation Analysis [Text Block] Schedule of Significant Expenses Provided to the CODM on a Regular Basis Reconciliation of Operating Profit (Loss) from Segments to Consolidated [Table Text Block] CURRENT LIABILITIES Liabilities, Current [Abstract] Paragon and License Agreement Paragon and License Agreement [Member] Paragon and License Agreement Total operating expenses Operating Expenses Rule 10b5-1 Arrangement Terminated Rule 10b5-1 Arrangement Terminated [Flag] Issuance of common stock in connection with exercise of stock options and employee stock purchase plan Stock Issued During Period, Value, Options Exercised And Employee Stock Ownership Plan Stock Issued During Period, Value, Options Exercised And Employee Stock Ownership Plan Level 1 Fair Value, Inputs, Level 1 [Member] Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items] Related Party Transaction [Table] Related Party Transaction [Table] Net loss per share, diluted (in dollars per share) Earnings Per Share, Diluted Asset acquisition, stockholder payment period (in years) Asset Acquisition, Stockholder Payment Period Asset Acquisition, Stockholder Payment Period Erroneously Awarded Compensation Recovery Erroneously Awarded Compensation Recovery [Table] Proceeds from raising capital Proceeds From Raising Capital Proceeds From Raising Capital Title of 12(b) Security Title of 12(b) Security Number of common shares issuable upon conversion (in shares) Preferred Stock, Convertible, Shares Issuable Disposal Groups, Including Discontinued Operations [Table] Disposal Groups, Including Discontinued Operations [Table] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items] Other comprehensive income (loss): Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] Number of shares of common stock sold (in shares) Number of shares sold (in shares) Sale of Stock, Number of Shares Issued in Transaction Related party accounts payable Increase (Decrease) in Other Accounts Payable Earnings Per Share [Abstract] Earnings Per Share [Abstract] Consolidation Items [Domain] Consolidation Items [Domain] Total other (expense) income Nonoperating Income (Expense) SPY003 License Agreement SPY003 License Agreement [Member] SPY003 License Agreement Schedule of Weighted-Average Equity Instruments Excluded from Calculation of Diluted Net Loss Per Share Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block] Marketable securities Marketable securities, estimated fair value Total marketable securities Debt Securities, Available-for-Sale, Current Segment, Reconciliation of Other Items from Segments to Consolidated [Table] Segment, Reconciliation of Other Items from Segments to Consolidated [Table] Outstanding Parapyre warrants Parapyre Warrants [Member] Parapyre Warrants Total related party accounts payable Accounts Payable, Other, Current Exercise price (in dollars per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price Service Based Awards Service Based Awards [Member] Service-based awards. Corporate bonds Corporate bonds Corporate bonds Corporate Bond Securities [Member] Fairmount Funds Management LLC Fairmount Funds Management LLC [Member] Fairmount Funds Management LLC. Award Timing Disclosures [Line Items] Contingent obligation based on milestones Amount To Be Paid Under Agreement Amount to be paid under agreement. Stock options, Weighted Average Grant Date Fair Value (in dollars per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Unrealized (loss) gain on marketable securities Unrealized gain on marketable securities OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Change in fair value of CVR liability Gain (Loss) on Derivative Instruments, Net, Pretax Net loss Net loss Net loss Allocation of losses Net Income (Loss) Attributable to Parent Schedule of Available-for-Sale Securities in an Unrealized Loss Position Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] Expiration Date Trading Arrangement Expiration Date Accrued other Other Accrued Liabilities, Current Amount of related party transaction Related Party Transaction, Amounts of Transaction Vest period grant date (in years) Share-based award, vesting period (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period 2018 Equity Inducement Plan Two Thousand And Eighteen Equity Inducement Plan [Member] 2018 equity inducement plan. Preferred stock, authorized (in shares) Preferred Stock, Shares Authorized Adoption Date Trading Arrangement Adoption Date Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Entity Current Reporting Status Entity Current Reporting Status Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Loss from operations Operating Income (Loss) Accumulated deficit Accumulated deficit Retained Earnings (Accumulated Deficit) Schedule of Stock-Based Compensation Expense Share-Based Payment Arrangement, Cost by Plan [Table Text Block] Financial Instrument [Axis] Financial Instrument [Axis] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Executive Category: Executive Category [Axis] 12 Months or Longer Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Company and Basis of Presentation [Line Items] Company and Basis of Presentation [Line Items] Company and basis of presentation. Class of Stock [Axis] Class of Stock [Axis] Current Fiscal Year End Date Current Fiscal Year End Date Expected term (in years) Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term Less Than 12 Months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Subsequent Event Type [Domain] Subsequent Event Type [Domain] Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Payables and Accruals [Abstract] Other (expense) income, net Other Nonoperating Income (Expense) Statement [Table] Statement [Table] CVR liability Derivative Liability Adjustments to reconcile net loss to net cash used in operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Earnings Per Share, Basic, by Common Class, Including Two-Class Method [Table] Licensing Agreements Collaborative Arrangement Disclosure [Text Block] CASH FLOWS FROM FINANCING ACTIVITIES Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Total, unrealized losses Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss Schedule of Fair Value of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block] The Company and Basis of Presentation Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block] Cash and Cash Equivalents [Abstract] Antidilutive securities excluded from computation of earnings per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] All Adjustments to Compensation All Adjustments to Compensation [Member] Amendment Flag Amendment Flag Sale of stock, price per share (in dollars per share) Sale of Stock, Price Per Share Other Paragon Reimbursable Expenses Other Paragon Reimbursable Expenses [Member] Other Paragon Reimbursable Expenses Termination Date Trading Arrangement Termination Date Net cash provided by financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Schedule of Related Party Accounts Payable and Other Current Liabilities Schedule Of Balances Due To Affiliates [Table Text Block] Schedule of balances due to affiliates. Measure: Measure [Axis] Weighted-average common stock outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Disposal Group Classification [Domain] Disposal Group Classification [Domain] Related Party Transaction [Domain] Related Party Transaction [Domain] Segment Reporting [Abstract] Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Risk-free interest Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate Other (expense) income: Nonoperating Income (Expense) [Abstract] Entity Tax Identification Number Entity Tax Identification Number Asset Acquisition [Axis] Asset Acquisition [Axis] Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Common stock, par value (in dollars per share) Common Stock, Par or Stated Value Per Share Schedule of Computation of Basic and Diluted Net Loss Per Share Schedule of Weighted Average Number of Shares [Table Text Block] Common stock, issued (in shares) Common Stock, Shares, Issued Options granted to purchase (in shares) Stock options, Grants (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Trading Arrangement: Trading Arrangement [Axis] SPY002 and SPY072 License Agreement SPY002 And SPY 072 License Agreement [Member] SPY002 And SPY 072 License Agreement Total Shareholder Return Amount Total Shareholder Return Amount Increase in fair value of derivative Changes in the fair value of the CVR liability Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Liability, Gain (Loss) Included in Earnings Estimated probability of success Measurement Input, Proability Of Success [Member] Measurement Input, Proability Of Success Insider Trading Arrangements [Line Items] Security Exchange Name Security Exchange Name Allowance for credit loss Debt Securities, Available-for-Sale, Allowance for Credit Loss, Excluding Accrued Interest 2016 Employee Stock Purchase Plan 2016 ESPP Two Thousand And Sixteen Employee Stock Purchase Plan [Member] Two thousand and sixteen employee stock purchase plan. TOTAL LIABILITIES Liabilities Antidilutive Securities, Name [Domain] Antidilutive Securities, Name [Domain] Cash and Cash Equivalents [Axis] Cash and Cash Equivalents [Axis] CVR liability CVR Liability Contingent Value Right Liability [Member] Contingent Value Right Liability Interest income Investment Income, Net Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Proceeds from maturities and sales of marketable securities Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Operating expenses: Operating Expenses [Abstract] Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Issuance of common stock in connection with at-the-market offering program, net of financing costs Stock Issued During Period, Value, New Issues Statement [Line Items] Statement [Line Items] Consolidation Items [Axis] Consolidation Items [Axis] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents Cash and Cash Equivalent Common stock available for future issuance, additional amount authorized (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized Common Stock Common Stock Common Stock [Member] Financial assets Debt Securities, Available-for-Sale Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] NET DECREASE IN CASH AND CASH EQUIVALENTS Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Accrued professional and consulting fees Accrued Professional Fees, Current