Licensing Agreements (Details) - USD ($)				3 Months Ended		12 Months Ended
		Oct. 11, 2024	May 14, 2024	Mar. 31, 2026	Mar. 31, 2025	Dec. 31, 2025
Related Party Transaction [Line Items]
Research and development	[1]			$ 60,411,000	$ 41,623,000
Related Party
Related Party Transaction [Line Items]
Research and development				$ 3,100,000	2,500,000
Paragon Agreement | Related Party
Related Party Transaction [Line Items]
Campaign timeline, minimum term (in years)				5 years
Royalty step-down (as percent)				33.00%
Royalty term expiration period (in years)				12 years
Termination notice period (in days)				60 days
Cash milestone payments				$ 3,000,000.0	0
Milestone payments, outstanding and payable				0		$ 0
Payment for sublicensing fee				0	500,000
SPY001 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment			$ 3,000,000.0
SPY002 and SPY072 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment			3,000,000.0
SPY003 License Agreement | Related Party
Related Party Transaction [Line Items]
First milestone payment		$ 3,000,000.0
License Agreement | Related Party
Related Party Transaction [Line Items]
Research and development				3,000,000.0	$ 2,500,000
Sublicensing fee, outstanding and payable				0		$ 0
Maximum | SPY001 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones			22,000,000.0
Maximum | SPY002 and SPY072 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones			$ 22,000,000.0
Sublicensing fee				$ 20,000,000
Maximum | SPY003 License Agreement | Related Party
Related Party Transaction [Line Items]
Contingent obligation based on milestones		$ 22,000,000.0

[1] Includes $3.1 million and $2.5 million in related party expenses for the three months ended March 31, 2026 and 2025, respectively.