Stock-Based Compensation - Schedule of Stock-Based Compensation Expense (Details) - USD ($)	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Stock-based compensation	$ 37,614,000	$ 44,833,000	$ 25,675,000
Related Party
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Stock-based compensation	1,000,000.0	15,600,000	11,500,000
Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	36,588,000	28,945,000	14,237,000
Stock-based compensation	36,600,000	28,900,000	14,200,000
Non- Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	1,026,000	15,888,000	11,438,000
Legacy Aeglea Employees and Directors
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Stock-based compensation	0	3,600,000	8,300,000
Research and Development Expense | Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	16,270,000	9,112,000	2,910,000
Research and Development Expense | Non- Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	0	14,459,000	11,328,000
General and administrative | Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	20,318,000	19,833,000	11,327,000
General and administrative | Non- Employees
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Total stock-based compensation expense	1,026,000	1,429,000	110,000
Parapyre Option Obligation
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Stock-based compensation	0
Parapyre Option Obligation | Related Party
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]
Stock-based compensation	$ 0	$ 14,500,000	$ 11,400,000