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Stock-Based Compensation (Tables)
 9 Months Ended
Sep. 30, 2025
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock Awards Granted Under all Equity Incentive and Inducement Plans
The following table summarizes the Company’s stock awards granted under all equity incentive and inducement plans for each of the periods indicated:
Three Months Ended September 30,Nine Months Ended September 30,
2025202420252024
GrantsWeighted Average Grant Date Fair ValueGrantsWeighted Average Grant Date Fair ValueGrantsWeighted Average Grant Date Fair ValueGrantsWeighted Average Grant Date Fair Value
Stock options213,900$15.88 425,500$25.74 2,539,617$19.94 1,857,853$28.40 
Schedule of Total Stock-Based Compensation Expense
Total stock-based compensation expense recognized from the Company’s equity incentive plans, 2018 Plan, 2016 ESPP and Parapyre Option Obligation during the periods presented was as follows (in thousands):
Three Months Ended
September 30,		Nine Months Ended
September 30,
2025202420252024
Research and development (1)
$4,248 $8,555 $11,860 $18,863 
General and administrative5,318 4,545 15,943 16,754 
Total stock-based compensation expense (2)
$9,566 $13,100 $27,803 $35,617 
(1) For the three and nine months ended September 30, 2024, $6.1 million and $13.0 million, respectively was recognized as stock compensation expense related to the Parapyre Option Obligation.
(2) Of the total $13.1 million and $35.6 million of stock-based compensation expense for the three and nine months ended September 30, 2024, respectively, $0.1 million and $3.6 million is related to legacy Aeglea employees and directors who had been terminated as of the end of the period, respectively.
Schedule of Weighted-Average Black-Scholes Option Pricing Model Assumptions Used to Estimate the Fair Value of Stock Options Granted
The following table summarizes the weighted-average Black-Scholes option pricing model assumptions used to estimate the fair value of stock options granted under the Company's equity incentive plans, and the shares purchased under the 2016 ESPP during the periods presented:
Three Months Ended
September 30,		Nine Months Ended
September 30,
2025202420252024
Stock Options Granted
Expected term (in years)6.086.085.986.02
Expected volatility75%105%76%105%
Risk-free interest3.92%4.13%4.34%4.03%
Dividend yield————
 
2016 ESPP
Expected term (in years)0.380.500.440.50
Expected volatility72%71%70%83%
Risk-free interest4.21%5.02%4.22%5.15%
Dividend yield————