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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The increase or decrease in number of shares reserved for issuance under stock option agreements awarded under the plan that validly exist and are outstanding, including vested options.

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Number of shares issued under share-based payment arrangement.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Purchase price of common stock expressed as a percentage of its fair value.

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Stock-Based Compensation - Narrative (Details) - USD ($)	1 Months Ended							12 Months Ended
	Nov. 30, 2023	Feb. 28, 2023	Oct. 31, 2018	Jun. 30, 2018	Feb. 28, 2018	Apr. 30, 2016	Mar. 31, 2015	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022	Jan. 01, 2024	Sep. 29, 2023	Jun. 22, 2023	Jan. 01, 2023	Jan. 01, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Outstanding option awards (in shares)								9,253,158	8,497,395
Stock-based compensation								$ 44,833,000	$ 25,675,000	$ 7,111,000
Equity instruments other than options, vested (in shares)								38,000
Tax benefits recognized								$ 0	$ 0	$ 0
Dividend yield								0.00%	0.00%	0.00%
Related Party
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation								$ 15,600,000	$ 11,400,000	$ 0
Paragon Agreement \| Related Party
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock-based compensation								14,500,000	$ 11,400,000
Parapyre Option Obligation
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Percentage of annual grant of common stock outstanding for warrants													1.00%
Warrants term												10 years
Stock-based compensation										$ 0
Warrant unamortized expense								$ 0
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average grant date fair value (in dollars per share)								$ 28.39	$ 9.67	$ 1.80
Intrinsic value of options exercised								$ 22,700,000	$ 400,000	$ 700,000
Unrecognized stock-based compensation expense for options								$ 85,200,000
Weighted average period over which unrecognized compensation is expected to be recognized								2 years 10 months 24 days
Dividend yield								0.00%	0.00%	0.00%
Stock Options \| Non- Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock option issued (in shares)								10,000	477,000	0
Stock option vested (in shares)								139,187	0	0
Unvested restricted stock units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)								0	153,865	0
Unvested restricted stock units \| Non- Employees
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Granted (in shares)								0	0	0
Performance Shares
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expense recognized for unvested employee and non-employee awards								$ 0	$ 0	$ 0
2015 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Percentage of market value of common stock							100.00%
Grantees with more than five years vesting term, percent							10.00%
Maximum vesting term for more than ten percent grantees							5 years
Shares subject to options outstanding (in shares)								952
Available for issuance (in shares)						20,395
2015 Equity Incentive Plan \| Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Awards granted, expiration period							10 years
2016 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Initial reserves of common stock (in shares)						44,000
Increase in common stock reserved for issuance (in shares)			70,384
Annual percentage of additional shares	5.00%		4.00%
Additional shares authorized (in shares)	4,481,152
Annual limit for non-employee director compensation (in shares)						4,000
Annual limit for non-employee director compensation	$ 750,000
Non-employee director compensation	$ 1,000,000
Additional common stock available for issuance (in shares)											3,023,650			104,561	78,968
Shares reserved for issuance (in shares)								7,193,219
Outstanding option awards (in shares)								3,145,248
2018 Equity Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Initial reserves of common stock (in shares)					44,000
Additional shares authorized (in shares)								1,000,000	6,000,000
Shares reserved for issuance (in shares)								6,895,602
Outstanding option awards (in shares)								6,219,622
2018 Plan, 2016 Plan and 2015 Plan \| Service Based Awards
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Awards granted, expiration period					10 years
Awards granted, vesting period					4 years
Spyre 2023 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Outstanding option awards (in shares)													2,734
2016 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Awards granted, expiration period						10 years
Additional common stock available for issuance (in shares)											360,571			26,140	19,742
Shares reserved for issuance (in shares)						6,600		416,592
Percentage of fair market value of common stock						85.00%
Percentage of discount through payroll deductions to eligible employees to purchase common stock						15.00%
Maximum purchase value per employee under employee stock purchase plan						$ 25,000
Additional annual percentage increase of common stock				1.00%
Maximum shares purchased under employee stock purchase plan (in shares)		400				80
Stock-based compensation expense								$ 300,000	$ 100,000	$ 200,000
Dividend yield								0.00%	0.00%	0.00%