Convertible Preferred Stock and Stockholders’ Equity - Narrative (Details)											1 Months Ended		3 Months Ended	12 Months Ended
	Nov. 29, 2024 USD ($) $ / shares	Nov. 20, 2024 shares	May 14, 2024 shares	Apr. 23, 2024 shares	Mar. 20, 2024 USD ($) $ / shares shares	Mar. 18, 2024 shares	Dec. 11, 2023 USD ($) $ / shares shares	Jul. 07, 2023 shares	Jun. 26, 2023 USD ($) $ / shares shares	Jun. 22, 2023	Jun. 30, 2023 shares	May 31, 2022 USD ($) $ / shares shares	Dec. 31, 2024 Vote $ / shares shares	Dec. 31, 2024 USD ($) Vote $ / shares shares	Dec. 31, 2023 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) shares	Feb. 27, 2025 USD ($)	Sep. 06, 2024 USD ($)	Apr. 25, 2024 shares	Dec. 08, 2023	Dec. 31, 2021 shares
Class Of Stock [Line Items]
Shares authorized (in shares)													410,000,000	410,000,000
Common stock, authorized (in shares)													400,000,000	400,000,000
Preferred stock, authorized (in shares)													10,000,000	10,000,000
Convertible preferred stock, par value (in dollars per share) | $ / shares													$ 0.0001	$ 0.0001
Common stock, par value (in dollars per share) | $ / shares													$ 0.0001	$ 0.0001	$ 0.0001
Number of votes for common stock holders | Vote													1	1
Common stock dividends declared | $														$ 0	$ 0
Warrants to purchase shares (in shares)												694,892
Offering price of warrant (in dollars per share) | $ / shares												$ 39.9975
Exercise price per warrant (in dollars per share) | $ / shares												$ 0.0025
Net proceeds from sale of common stock | $												$ 42,900,000
Placement agent fees and offering costs | $												$ 2,100,000
Issuance of Series B non-voting convertible preferred stock in connection with private placement, net of financing costs (in shares)							150,000							122,000	150,000
Maximum ownership percentage of common stock shares for outstanding warrants to be exercised												4.99%
Ownership percentage for outstanding warrants to purchase shares of common stock to be exercised to certain holders												9.99%
Maximum ownership percentage of common stock shares for outstanding warrants to be exercised upon written notice												19.90%
Revised ownership percentage, period to take effect after notice												61 days
Number of warrants outstanding (in shares)													0	0
Parapyre Warrants
Class Of Stock [Line Items]
Warrants to purchase shares (in shares)													848,184	848,184	684,407
Exercise price per warrant (in dollars per share) | $ / shares													$ 23.28	$ 23.28	$ 21.52
Number of warrants exercised (in shares)													0	0
Private Placement
Class Of Stock [Line Items]
Public offering price (in dollars per share) | $ / shares									$ 291.08
Sale of stock (in shares)									721,452		721,452
Aggregate purchase price for stock sold | $					$ 168,900,000		$ 84,600,000		$ 197,300,000
Offering costs | $					$ 11,200,000		$ 5,400,000		$ 12,700,000
Proceeds from issuance of private placement, net | $														$ 180,000,000.0
At-The-Market Offering
Class Of Stock [Line Items]
Sale of stock, authorized amount | $																		$ 500,000,000.0
Common Stock
Class Of Stock [Line Items]
Issuance of stock in connection with private placement, net of financing costs (in shares)												430,107
Public offering price (in dollars per share) | $ / shares												$ 40.00
Exchange of Series A non-voting convertible preferred stock for common stock (in shares)														3,640,000
Common Stock | Conversion Of Series A Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)													25,972,080
Common Stock | Conversion Of Series B Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)			10,198,320											10,198,320
Common Stock
Class Of Stock [Line Items]
Proceeds from issuance of private placement, net | $														$ 0	$ 84,555,000	$ 0
Exchange of Series A non-voting convertible preferred stock for common stock (in shares)				3,639,680
Common Stock | At-The-Market Offering
Class Of Stock [Line Items]
Public offering price (in dollars per share) | $ / shares													$ 26.935	$ 26.935
Sale of stock (in shares)														777,432
Aggregate purchase price for stock sold | $														$ 20,500,000
Offering costs | $														$ 400,000
Sale of stock, aggregate offering price | $																		$ 200,000,000.0
Common Stock | At-The-Market Offering | Subsequent Event
Class Of Stock [Line Items]
Sale of stock, remaining authorized amount available for sale | $																	$ 179,100,000
Common Stock | Underwritten Offering
Class Of Stock [Line Items]
Public offering price (in dollars per share) | $ / shares	$ 27.50
Sale of stock (in shares)		8,366,250
Aggregate purchase price for stock sold | $	$ 215,900,000
Offering costs | $	$ 14,200,000
Common Stock | Common Stock
Class Of Stock [Line Items]
Issuance of stock in connection with private placement, net of financing costs (in shares)															6,000,000
Series B Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Preferred stock, authorized (in shares)													271,625	271,625	271,625
Convertible preferred stock, par value (in dollars per share) | $ / shares													$ 0.0001	$ 0.0001	$ 0.0001
Issuance of Series B non-voting convertible preferred stock in connection with private placement, net of financing costs (in shares)					121,625	271,625	150,000
Proceeds from issuance of private placement, net | $														$ 168,850,000	$ 84,555,000	$ 0
Conversion basis					40		40													40
Preferred stock, outstanding (in shares)													16,667	16,667	16,667
Preferred stock, not automatically converted, outstanding (in shares)													16,667	16,667
Series B Non-Voting Convertible Preferred Stock | Minimum
Class Of Stock [Line Items]
Beneficial holders owned percentage														0.00%
Series B Non-Voting Convertible Preferred Stock | Maximum
Class Of Stock [Line Items]
Beneficial holders owned percentage														19.90%
Series B Non-Voting Convertible Preferred Stock | Private Placement
Class Of Stock [Line Items]
Public offering price (in dollars per share) | $ / shares					$ 1,480		$ 600
Aggregate purchase price for stock sold | $							$ 169,100,000
Offering costs | $							$ 10,900,000
Issuance of Series B non-voting convertible preferred stock in connection with private placement, net of financing costs (in shares)					121,625	271,625	150,000
Series B Non-Voting Convertible Preferred Stock | Common Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)														10,198,000
Series B Non-Voting Convertible Preferred Stock | Common Stock | Private Placement
Class Of Stock [Line Items]
Public offering price (in dollars per share) | $ / shares							$ 15.00
Sale of stock (in shares)							6,000,000
Series B Non-Voting Convertible Preferred Stock | Preferred Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)														(255,000)
Preferred stock, outstanding (in shares)													17,000	17,000	0	0					0
Series B Non-Voting Convertible Preferred Stock | Preferred Stock | Conversion Of Series B Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)			254,958											254,958
Series A Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Preferred stock, authorized (in shares)													1,086,341	1,086,341
Convertible preferred stock, par value (in dollars per share) | $ / shares													$ 0.0001	$ 0.0001	$ 0.0001
Proceeds from issuance of private placement, net | $														$ 0	$ 197,364,000	$ 0
Preferred stock issued and outstanding percentage										30.00%
Conversion basis										40
Preferred stock, outstanding (in shares)													346,045	346,045	437,037				346,045
Exchange of Series A non-voting convertible preferred stock for common stock (in shares)				90,992
Series A Non-Voting Convertible Preferred Stock | Minimum
Class Of Stock [Line Items]
Beneficial holders owned percentage										0.00%
Series A Non-Voting Convertible Preferred Stock | Maximum
Class Of Stock [Line Items]
Beneficial holders owned percentage										19.90%
Series A Non-Voting Convertible Preferred Stock | Common Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)															25,972,000
Series A Non-Voting Convertible Preferred Stock | Preferred Stock
Class Of Stock [Line Items]
Issuance of stock in connection with private placement, net of financing costs (in shares)															721,000
Issuance of Series A non-voting convertible preferred stock in connection with the asset acquisition of Spyre and settlement of related forward contract (in shares)								364,887							365,000
Conversion of non-voting convertible preferred stock into common stock (in shares)															(649,000)
Preferred stock, outstanding (in shares)													346,000	346,000	437,000	0					0
Exchange of Series A non-voting convertible preferred stock for common stock (in shares)														(91,000)
Series A Non-Voting Convertible Preferred Stock | Preferred Stock | Conversion Of Series A Non-Voting Convertible Preferred Stock
Class Of Stock [Line Items]
Conversion of non-voting convertible preferred stock into common stock (in shares)													649,302