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Segment Reporting (Tables)
 12 Months Ended
Dec. 31, 2024
Segment Reporting [Abstract]  
Summary of Significant Segment Expenses
The following table sets forth the significant expenses provided to the CODM on a regular basis (in thousands):
Year Ended December 31,
202420232022
Revenue$— $886 $2,329 
Less:
Compensation$21,780 $22,590 $25,776 
Share-based compensation (1)
44,833 25,675 7,111 
Research and development, excluding compensation and share-based compensation (2) (3)
127,491 65,282 40,700 
Other segment items (4)
13,914 226,129 12,557 
Segment net loss$208,018 $338,790 $83,815 
Reconciliation of net loss
Adjustments and reconciling items— — — 
Consolidated net loss$208,018 $338,790 $83,815 
(1)Includes $15.6 million and $11.4 million in related party expenses for the years ended December 31, 2024 and 2023, respectively, and no related party expenses for the year ended December 31, 2022.
(2)Includes non-clinical study expenses, clinical trial expenses and manufacturing costs.
(3)Includes $25.5 million and $37.1 million in related party expenses for the years ended December 31, 2024 and 2023, respectively, and no related party expenses for the year ended December 31, 2022.
(4)Includes general and administrative expenses such as audit, legal, and other professional fees, interest income, and Other expense, net. For the year ended December 31, 2023, includes acquired IPR&D expense related to the Asset Acquisition, a gain on sale related to sale of Pegzilarginase to Immedica, and changes in the forward-contract liability related to the Asset Acquisition.