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Stock-Based Compensation (Tables)
12 Months Ended
Dec. 31, 2024
Share-Based Payment Arrangement [Abstract]  
Employee and Non-Employee Stock Option Activity
The following table summarizes stock option activity for the year ended December 31, 2024:
Shares
Issuable
Under
Options
Weighted
Average
Exercise
Price
Weighted
Average
Remaining
Contractual
Term
Aggregate
Intrinsic
Value
(in years)
(in thousands)
Outstanding as of December 31, 20238,497,395$12.13 8.40$98,928 
Granted2,521,85328.39 
Exercised(912,382)7.90 
Forfeited(853,708)32.78 
Outstanding as of December 31, 20249,253,158$15.08 8.80$90,016 
Options vested and expected to vest as of December 31, 20249,253,158$15.08 8.80$90,016 
Options exercisable as of December 31, 20242,529,495$11.99 8.43$31,518 
Employee Restricted Stock Activity
The following table summarizes employee restricted stock unit activity for the year ended December 31, 2024:
Shares
Weighted
Average Grant
Date Fair Value
Unvested restricted stock units as of December 31, 2023153,865$18.17 
Granted— 
Vested(38,467)18.17 
Forfeited— 
Unvested restricted stock units as of December 31, 2024115,398$18.17 
Stock-Based Compensation Expense
Total stock-based compensation expense recognized from the Parapyre Option Obligation, the Company’s equity incentive plans, 2018 Plan, and the 2016 ESPP for the years ended December 31, 2024, 2023, and 2022 was as follows (in thousands):
Year Ended December 31,
202420232022
Employees
Non-
Employees
Employees
Non-
Employees
Employees
Non-
Employees
Research and development (1)
$9,112 $14,459 $2,910 $11,328 $2,591 $— 
General and administrative19,833 1,429 11,327 109 4,520 — 
Total stock-based compensation expense (2)
$28,945 $15,888 $14,237 $11,437 $7,111 $— 
(1)For the years ended December 31, 2024 and 2023, $14.5 million and $11.4 million, respectively, was recognized as stock compensation expense related to the Parapyre Option Obligation. There was no such expense for the year ended December 31, 2022.
(2)Of the total $28.9 million, $14.2 million and $7.1 million of employee related stock-based compensation expense for the years ended December 31, 2024, 2023 and 2022, respectively, $3.6 million, $8.3 million and $6.9 million is related to legacy Aeglea employees and directors who no longer served the Company as of the end of the respective period.
Weighted-Average Assumptions Used in Calculating Fair Value of Awards The following table summarizes the weighted-average assumptions used in calculating the fair value of the awards:
Year Ended December 31,
202420232022
Stock Options Granted
Expected term (in years)6.035.886.00
Expected volatility105 %107 %84 %
Risk-free interest4.06 %4.37 %2.93 %
Dividend yield%%%
2016 ESPP
Expected term (in years)0.500.490.49
Expected volatility84 %181 %84 %
Risk-free interest5.16 %4.99 %1.95 %
Dividend yield%%%