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Sale of Pegzilarginase to Immedica (Details) - USD ($)
3 Months Ended 9 Months Ended
Jul. 27, 2023
Sep. 30, 2023
Sep. 30, 2022
Sep. 30, 2023
Sep. 30, 2022
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]          
Proceeds from sale of intangible assets       $ 15,000,000 $ 0
Gain recognized within operating expenses   $ 14,609,000 $ 0 $ 14,609,000 $ 0
Disposal Group, Disposed of by Sale, Not Discontinued Operations | Global Rights To Pegzilarginase          
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]          
Proceeds from sale of intangible assets $ 15,000,000        
Contingent consideration 100,000,000        
Carrying value of assets 0        
Gain recognized within operating expenses $ 14,600,000