0001636282-26-000084.txt : 20260623 0001636282-26-000084.hdr.sgml : 20260623 20260623213223 ACCESSION NUMBER: 0001636282-26-000084 CONFORMED SUBMISSION TYPE: 4 PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20260622 FILED AS OF DATE: 20260623 DATE AS OF CHANGE: 20260623 REPORTING-OWNER: OWNER DATA: COMPANY CONFORMED NAME: HENDERSON MICHAEL THOMAS CENTRAL INDEX KEY: 0001779990 ORGANIZATION NAME: FILING VALUES: FORM TYPE: 4 SEC ACT: 1934 Act SEC FILE NUMBER: 001-37722 FILM NUMBER: 261112846 MAIL ADDRESS: STREET 1: 421 KIPLING STREET CITY: PALO ALTO STATE: CA ZIP: 94301 ISSUER: COMPANY DATA: COMPANY CONFORMED NAME: Spyre Therapeutics, Inc. CENTRAL INDEX KEY: 0001636282 STANDARD INDUSTRIAL CLASSIFICATION: PHARMACEUTICAL PREPARATIONS [2834] ORGANIZATION NAME: 03 Life Sciences EIN: 464312787 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 BUSINESS ADDRESS: STREET 1: 221 CRESCENT STREET STREET 2: BUILDING 23, SUITE 105 CITY: WALTHAM STATE: MA ZIP: 02453 BUSINESS PHONE: 6176515940 MAIL ADDRESS: STREET 1: 221 CRESCENT STREET STREET 2: BUILDING 23, SUITE 105 CITY: WALTHAM STATE: MA ZIP: 02453 FORMER COMPANY: FORMER CONFORMED NAME: Aeglea BioTherapeutics, Inc. DATE OF NAME CHANGE: 20150311 4 1 wk-form4_1782264740.xml FORM 4 X0609 4 2026-06-22 0 0001636282 Spyre Therapeutics, Inc. SYRE 0001779990 HENDERSON MICHAEL THOMAS false 221 CRESCENT STREET, BUILDING 23, SUITE 105 WALTHAM MA 02453 1 0 0 0 1 Common Stock 2026-06-22 4 S 0 20000 100 D 68606 D This transaction was executed pursuant to a Rule 10b5-1 trading plan adopted on February 6, 2026. /s/ Heidy King-Jones, as Attorney-in-Fact 2026-06-23