Income Taxes (Tables)

12 Months Ended

Dec. 31, 2021

Schedule of Loss Income Before Income Tax Expense by Jurisdiction

The following table summarizes the (loss) income before income tax expense by jurisdiction for the periods indicated:

	Year Ended December 31,
	2021			2020			2019
Domestic	$	(65,940	)	$	(80,893	)	$	(78,254	)
Foreign		280			—			—
Loss before income tax expense	$	(65,660	)	$	(80,893	)	$	(78,254	)

Summary of Difference Between Provision for Income Taxes and Amounts Computed by Applying Statutory Federal Income Tax Rate to Income Before Income Taxes

The difference between the Company’s provision for income taxes and the amounts computed by applying the statutory federal income tax rate to income before income taxes is as follows (in thousands):

	Year Ended December 31,
	2021			2020			2019
Tax provision derived by applying the federal statutory rate to income before income taxes	$	(13,789	)	$	(16,988	)	$	(16,433	)
Permanent differences and other		1,002			482			(98	)
Federal tax credits		(3,815	)		(3,905	)		(3,599	)
State tax credits		(152	)		(251	)		(229	)
Effect of tax rate on foreign jurisdiction		(5	)		—			—
Change in the valuation allowance		16,900			20,662			20,359
Income tax expense	$	141		$	—		$	—

Components of Deferred Tax Assets and Liabilities

The components of the deferred tax assets and liabilities consist of the following (in thousands):

	December 31,
	2021			2020
Deferred tax assets
Net operating loss carryforward	$	64,531		$	51,708
Intangible assets		57			51
Accrued expense		846			598
Stock-based compensation		2,767			2,087
Federal tax credits		18,579			14,764
State tax credits		991			839
Other		220			299
Total deferred tax assets		87,991			70,346
Deferred tax liabilities
Depreciable assets		(948	)		(203	)
Total deferred tax liabilities		(948	)		(203	)
Less: Valuation allowance		(87,043	)		(70,143	)
Deferred tax assets, net	$	—		$	—