Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (80,893)	$ (78,254)	$ (44,348)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	996	418	293
Purchase net (premium) discount on marketable securities	(286)	504	907
Net amortization of premium (accretion of discount) on marketable securities	73	(818)	(593)
Stock-based compensation	6,256	4,876	4,280
Research and development services settled with stock			107
Non-cash operating lease expense	628	483
Other	(9)	(5)	(40)
Changes in operating assets and liabilities:
Accounts receivable - grant			3,078
Prepaid expenses and other assets	(1,101)	(346)	(261)
Accounts payable	(544)	2,583	239
Deferred revenue			(20)
Operating lease liabilities	251	(258)
Accrued and other liabilities	(1,146)	5,125	4,165
Net cash used in operating activities	(75,775)	(65,692)	(32,193)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(4,280)	(1,492)	(422)
Purchases of marketable securities	(129,000)	(91,926)	(62,179)
Proceeds from maturities and sales of marketable securities	125,676	91,679	47,370
Net cash used in investing activities	(7,604)	(1,739)	(15,231)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from issuance of common stock and pre-funded warrants in public and at-the-market offerings, net of offering costs	153,716	64,298	54,048
Proceeds from employee stock plan purchases and stock option exercises	816	1,450	3,020
Principal payments on finance lease obligation	(20)	(25)
Net cash provided by financing activities	154,512	65,723	57,068
Effect of exchange rate on cash, cash equivalents, and restricted cash	51
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH	71,184	(1,708)	9,644
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH
Beginning of period	20,753	22,461	12,817
End of period	91,937	20,753	22,461
Supplemental Disclosure of Non-Cash Investing and Financing Information:
Leased assets obtained in exchange for lease obligations	172	5,294
Unpaid amounts related to purchase of property and equipment	$ 224	$ 356	$ 92

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