Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (78,254)	$ (44,348)	$ (27,236)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	418	293	249
Purchase net discount on marketable securities	504	907	9
Net (accretion of discount) amortization of premium on marketable securities	(818)	(593)	75
Stock-based compensation	4,876	4,280	2,492
Research and development services settled with stock		107	15
Non-cash operating lease expense	483
Other, net	(5)	(40)	(21)
Changes in operating assets and liabilities:
Accounts receivable - grant		3,078	(1,863)
Prepaid expenses and other assets	(346)	(261)	(114)
Accounts payable	2,583	239	164
Deferred revenue		(20)	(51)
Operating lease liabilities	(258)
Accrued and other liabilities	5,125	4,165	1,666
Net cash used in operating activities	(65,692)	(32,193)	(24,615)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(1,492)	(422)	(619)
Purchases of marketable securities	(91,926)	(62,179)	(64,115)
Proceeds from maturities and sales of marketable securities	91,679	47,370	42,205
Net cash used in investing activities	(1,739)	(15,231)	(22,529)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from issuance of common stock and pre-funded warrants in public and at-the-market offerings, net of offering costs	64,298	54,048	11,380
Proceeds from employee stock plan purchases and stock option exercises	1,450	3,020	833
Principal payments on finance lease obligation	(25)
Net cash provided by financing activities	65,723	57,068	12,213
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH	(1,708)	9,644	(34,931)
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH
Beginning of period	22,461	12,817	47,748
End of period	20,753	22,461	12,817
Supplemental Disclosure of Non-Cash Investing and Financing Information:
Leased assets obtained in exchange for lease obligations	5,294
Unpaid amounts related to purchase of property and equipment	$ 356	$ 92	$ 57

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