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Stock-Based Compensation - Schedule of Estimate Fair Value of Stock Options Granted (Details)
3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
2016 Plan and 2018 Plan        
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]        
Expected term (in years) 6 years 5 years 9 months 25 days 5 years 11 months 15 days 5 years 10 months 28 days
Expected volatility 84.00% 85.00% 85.00% 86.00%
Risk-free interest 2.80% 1.88% 2.75% 1.99%
Dividend yield 0.00% 0.00% 0.00% 0.00%
2016 Employee Stock Purchase Plan        
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]        
Expected term (in years) 6 months 6 months 5 months 26 days 6 months
Expected volatility 63.00% 79.00% 66.00% 79.00%
Risk-free interest 2.45% 1.23% 2.20% 0.90%
Dividend yield 0.00% 0.00% 0.00% 0.00%