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Stock-Based Compensation - Schedule of Estimate Fair Value of Stock Options Granted (Details)
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Equity Incentive Plans    
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]    
Expected term 6 years 3 days 5 years 11 months 26 days
Expected volatility 85.00% 86.00%
Risk-free interest 2.72% 2.13%
Dividend yield 0.00% 0.00%
2016 Employee Stock Purchase Plan    
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]    
Expected term 5 months 26 days 6 months
Expected volatility 69.00% 79.00%
Risk-free interest 2.00% 0.68%
Dividend yield 0.00% 0.00%