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Share/Stock-Based Compensation - Summary of Weighted-Average Assumptions Used in Calculating Fair Value of Awards (Details)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]      
Dividend yield 0.00%    
2016 Plan and 2015 Plan      
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]      
Expected term 5 years 10 months 17 days 5 years 11 months 27 days 6 years 3 months 15 days
Expected volatility 86.00% 87.00% 87.00%
Risk-free interest 2.00% 1.28% 1.37%
Dividend yield 0.00% 0.00% 0.00%
2016 Employee Stock Purchase Plan      
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]      
Expected term 6 months 5 months 12 days  
Expected volatility 78.00% 82.00%  
Risk-free interest 1.06% 0.50%  
Dividend yield 0.00% 0.00%