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Stock-Based Compensation - Schedule of Estimate Fair Value of Stock Options Granted (Details)
3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Equity Incentive Plans        
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]        
Expected term 5 years 11 months 15 days 6 years 5 years 11 months 26 days 6 years
Expected volatility 86.00% 87.00% 86.00% 87.00%
Risk-free interest 1.87% 1.29% 2.07% 1.29%
Dividend yield 0.00% 0.00% 0.00% 0.00%
2016 Employee Stock Purchase Plan        
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]        
Expected term   4 months 9 days 6 months 4 months 9 days
Expected volatility   85.00% 79.00% 85.00%
Risk-free interest   0.36% 0.68% 0.36%
Dividend yield   0.00% 0.00% 0.00%