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Stock-Based Compensation - Schedule of Estimate Fair Value of Stock Options Granted (Details)
3 Months Ended 9 Months Ended
Sep. 30, 2016
Sep. 30, 2016
Sep. 30, 2015
2016 Plan and 2015 Plan      
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]      
Expected term 6 years 26 days 5 years 11 months 27 days 6 years 3 months 15 days
Expected volatility 81.00% 87.00% 87.00%
Risk-free interest 1.16% 1.28% 1.37%
Dividend yield 0.00% 0.00% 0.00%
2016 Employee Stock Purchase Plan      
Employee Service Share Based Compensation Allocation of Recognized Period Costs [Line Items]      
Expected term 6 months 5 months 12 days  
Expected volatility 81.00% 82.00%  
Risk-free interest 0.57% 0.49%  
Dividend yield 0.00% 0.00%