144 0001802528 XXXXXXXX LIVE 0001636282 Spyre Therapeutics, Inc. 001-37722 221 Crescent Street Building 23 Waltham MA 02453 617-651-5940 Fairmount Healthcare Fund II L.P. Director Common Goldman Sachs & Co. LLC

200 West Street New York NY 10282

4684781 399658667.00 86841253 06/23/2026 NASDAQ Common 06/22/2023 Acquired in reverse merger transaction Issuer N 378421 06/22/2023 Acquired in reverse merger transaction Common 04/25/2024 Exchange of Series A Non-Voting Convertible Preferred Stock Issuer N 3639680 04/25/2024 Exchange of Series A Non-Voting Convertible Preferred Stock into Common Stock Common 06/23/2026 Conversion of Series B Non-Voting Convertible Preferred Stock Issuer N 666680 06/23/2026 Conversion of Series B Non-Voting Convertible Preferred Stock into Common Stock Y Fairmount Funds Management LLC ("Fairmount") is the investment manager for Fairmount Healthcare Fund II L.P. The managers of Fairmount are Peter Harwin and Tomas Kiselak. Tomas Kiselak is also a director of the Issuer. 06/23/2026 /s/ Tomas Kiselak for Fairmount Funds Management LLC