Condensed Consolidated Statements of Changes in Convertible Preferred Stock and Stockholders' (Deficit) Equity (Unaudited) - USD ($) shares in Thousands	Total	Preferred Stock Series A Preferred Stock	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Balances at Dec. 31, 2021	$ 83,941,000		$ 5,000	$ 425,765,000	$ (20,000)	$ (341,809,000)
Balances (in shares) at Dec. 31, 2021			49,355
Issuance of common stock in connection with employee stock purchase plan	184,000			184,000
Issuance of common stock in connection with employee stock purchase plan (in shares)			65
Stock-based compensation expense	2,101,000			2,101,000
Foreign currency translation adjustment	(13,000)				(13,000)
Unrealized gain (loss) on marketable securities	(120,000)				(120,000)
Net loss	(24,436,000)					(24,436,000)
Balances at Mar. 31, 2022	61,657,000		$ 5,000	428,050,000	(153,000)	(366,245,000)
Balances (in shares) at Mar. 31, 2022			49,420
Balances at Dec. 31, 2021	83,941,000		$ 5,000	425,765,000	(20,000)	(341,809,000)
Balances (in shares) at Dec. 31, 2021			49,355
Foreign currency translation adjustment	(49,000)
Unrealized gain (loss) on marketable securities	(151,000)
Net loss	(46,759,000)
Balances at Jun. 30, 2022	84,157,000		$ 6,000	472,939,000	(220,000)	(388,568,000)
Balances (in shares) at Jun. 30, 2022			61,173
Balances at Mar. 31, 2022	61,657,000		$ 5,000	428,050,000	(153,000)	(366,245,000)
Balances (in shares) at Mar. 31, 2022			49,420
Issuance of common stock and pre-funded warrants in connection with registered direct offering, net of offering costs	42,873,000		$ 1,000	42,872,000
Issuance of common stock and pre-funded warrants in connection with registered direct offering, net of offering costs (in shares)			10,753
Issuance of common stock in connection with exercise of pre-funded warrants (in shares)			1,000
Stock-based compensation expense	2,017,000			2,017,000
Foreign currency translation adjustment	(36,000)				(36,000)
Unrealized gain (loss) on marketable securities	(31,000)				(31,000)
Net loss	(22,323,000)					(22,323,000)
Balances at Jun. 30, 2022	84,157,000		$ 6,000	472,939,000	(220,000)	(388,568,000)
Balances (in shares) at Jun. 30, 2022			61,173
Balances at Dec. 31, 2022	50,305,000		$ 6,000	475,971,000	(48,000)	(425,624,000)
Balances (in shares) at Dec. 31, 2022			65,350
Issuance of common stock in connection with employee stock purchase plan	18,000			18,000
Issuance of common stock in connection with employee stock purchase plan (in shares)			45
Stock-based compensation expense	1,709,000			1,709,000
Foreign currency translation adjustment	10,000				10,000
Unrealized gain (loss) on marketable securities	32,000				32,000
Net loss	(18,422,000)					(18,422,000)
Balances at Mar. 31, 2023	33,652,000		$ 6,000	477,698,000	(6,000)	(444,046,000)
Balances (in shares) at Mar. 31, 2023			65,395
Balances at Dec. 31, 2022	50,305,000		$ 6,000	475,971,000	(48,000)	(425,624,000)
Balances (in shares) at Dec. 31, 2022			65,350
Foreign currency translation adjustment	28,000
Unrealized gain (loss) on marketable securities	31,000
Net loss	(235,503,000)
Balances at Jun. 30, 2023	(207,369,000)		$ 6,000	453,741,000	11,000	(661,127,000)
Balances (in shares) at Jun. 30, 2023			81,002
Balances at Jun. 30, 2023		$ 197,323,000
Balances (in shares) at Jun. 30, 2023		721
Balances at Mar. 31, 2023	33,652,000		$ 6,000	477,698,000	(6,000)	(444,046,000)
Balances (in shares) at Mar. 31, 2023			65,395
Issuance of Series A non-voting convertible preferred stock in connection with private placement, net of financing costs		$ 197,323,000
Issuance of Series A non-voting convertible preferred stock in connection with private placement, net of financing costs, (in shares)		721
Issuance of common stock forward in connection with the asset acquisition of Spyre	3,768,000			3,768,000
Issuance of common stock in connection with exercise of pre-funded warrants (in shares)			15,607
CVR distribution to common stockholders	(29,500,000)			(29,500,000)
Stock-based compensation expense	1,775,000			1,775,000
Foreign currency translation adjustment	18,000				18,000
Unrealized gain (loss) on marketable securities	(1,000)				(1,000)
Net loss	(217,081,000)					(217,081,000)
Balances at Jun. 30, 2023	$ (207,369,000)		$ 6,000	$ 453,741,000	$ 11,000	$ (661,127,000)
Balances (in shares) at Jun. 30, 2023			81,002
Balances at Jun. 30, 2023		$ 197,323,000
Balances (in shares) at Jun. 30, 2023		721