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Liabilities, Convertible Preferred Stock and Stockholders' (Deficit) Equity - Additional Information (Details) - USD ($)			1 Months Ended		3 Months Ended		6 Months Ended
	Jun. 22, 2023	Jan. 01, 2023	May 31, 2022	Jul. 31, 2020	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Aug. 04, 2023	Jan. 01, 2022
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Warrants to purchase shares			17,372,312
Offering price of warrant			$ 1.5999
Exercise price per warrant			$ 0.0001
Net proceeds from sale of common stock			$ 42,900,000
Placement agent fees and offering costs			$ 2,100,000
Maximum ownership percentage of common stock shares for outstanding warrants to be exercised							4.99%
Ownership percentage for outstanding warrants To purchase shares of common stock to be exercised to certain holders							9.99%
Period after notice received by company maximum ownership percentage to be effective description							The revised Maximum Ownership Percentage would be effective 61 days after the notice is received by the Company.
Stock-based compensation expense					$ 1,911,000	$ 2,018,000	$ 3,620,000	$ 4,118,000
Options granted					63,417,415	429,000
Stock-based compensation							$ 3,620,000	$ 4,118,000
Subsequent Event
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Pre-funded warrants exercised									7,031,250
2016 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Annual percentage of additional shares		4.00%
Additional number of shares available for issuance		2,614,013								1,974,205
Common stock available for future issuance					5,384,315		5,384,315
Expense on contingent awards					$ 0		$ 0
Stock options granted to certain members of board of directors, contingent on stockholder approval	68,000,955
2016 Equity Incentive Plan \| Restricted Stock Units RSU
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares, granted to employees				228,200
Stock-based compensation expense							$ 0
2016 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock option to purchase an aggregate of common stock shares							44,816	64,743
Aggregate cash proceeds from sale of shares								$ 200,000
2018 Equity Inducement Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Additional number of shares available for grant	70,000,000
Vest period grant date	4 years
Exercise period grant date	10 years
Exercise price	$ 0.30
Options granted	63,417,415
Spyre 2023 Equity Incentive Plan \| Asset Acquisition
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Outstanding and unexercised stock options	68,365
Parapyre Option Obligation
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unamortized expense					1,300,000		$ 1,300,000
Annual percentage of additional shares	1.00%
Stock-based compensation					$ 200,000		200,000
Fair value of Parapyre Options assumed	$ 100,000						100,000
Pro-rated estimated fair value of options							$ 300,000
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Maximum ownership percentage of common stock shares for outstanding warrants to be exercised							19.99%
Maximum \| 2016 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Aggregate cash proceeds from sale of shares							$ 100,000
Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of shares issued			10,752,688
Public offering price			$ 1.60