X0306 4 2020-04-08 0 0001634432 Strongbridge Biopharma plc SBBP 0001410781 JOHNSON JOHN 900 NORTHBROOK DRIVE SUITE 200 TREVOSE PA 19053 1 1 0 0 Executive Chairman Ordinary Shares 2020-04-08 4 A 0 182500 0 A 222500 D Employee Stock Option (right to buy) 1.90 2020-04-08 4 A 0 87500 0 A 2030-04-08 Common Stock 87500 87500 D Represents a grant of restricted stock units, which vest in three equal annual installments on each of the first three anniversaries of the grant date, provided that the Reporting Person continues to serve as Executive Chairman and as a member of the board of directors of the Issuer through each such vesting date. Each restricted stock unit represents a contingent right to receive one ordinary share of the Issuer. This option vests in sixteen equal quarterly installments beginning May 8, 2020, provided that the Reporting Person continues to serve as Executive Chairman and as a member of the board of directors of the Issuer through each such vesting date. /s/ Stephen J. Long, as attorney-in-fact 2020-04-10