X0306 4 2023-01-26 0 0001634379 Metacrine, Inc. MTCR 0001493056 Klassen Preston C/O METACRINE, INC. 4225 EXECUTIVE SQUARE, SUITE 600 SAN DIEGO CA 92037 1 1 0 0 President & CEO Common Stock 2023-01-26 4 S 0 380605 0.4132 D 541905 D Sale of shares to cover tax withholding obligations associated with the vesting of the restricted stock unit award granted to the Reporting Person on February 27, 2022. The price reported in Column 4 is an average weighted sales price. These shares were sold in multiple transactions at prices ranging from $.4114 to $.4501, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth above. /s/ Preston Klassen 2023-01-27