X0306 4 2022-02-27 0 0001634379 Metacrine, Inc. MTCR 0001493056 Klassen Preston C/O METACRINE, INC. 3985 SORRENTO VALLEY BLVD., SUITE C SAN DIEGO CA 92121 1 1 0 0 President & CEO Common Stock 2022-02-27 4 A 0 842211 0.00 A 862758 D Stock option (right to buy) 0.47 2022-02-27 4 A 0 842211 0.00 A 2032-02-26 Common Stock 842211 842211 D Represents the number of shares of Common Stock issued to the Reporting Person pursuant to an award of restricted stock units. The award vests in full on February 27, 2023, subject to the Reporting Person's continued service to the Issuer. 50% of the shares of Common Stock subject to the stock option shall vest and become exercisable on February 27, 2023, and the remaining shares shall vest and become exercisable in equal installments on the last day of each of the following 12 months until fully vested on February 27, 2024, subject to the Reporting Person's continued service to the Issuer on each such vesting date. /s/ Preston Klassen 2022-03-01