X0306 4 2021-05-20 0 0001634379 Metacrine, Inc. MTCR 0001493056 Klassen Preston C/O METACRINE, INC. 3985 SORRENTO VALLEY BLVD., SUITE C SAN DIEGO CA 92121 1 1 0 0 President & CEO Common Stock 2021-05-20 4 P 0 20547 3.6352 A 20547 D The reported price in Column 4 is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $3.62 to 3.64 per share, inclusive. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the range set forth in this footnote. /s/ Catherine C. Lee, Attorney-in-fact 2021-05-20