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      <amendmentNo>2</amendmentNo>
      <securitiesClassTitle>Common Shares</securitiesClassTitle>
      <dateOfEvent>10/09/2025</dateOfEvent>
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        <issuerCUSIP>29668H708</issuerCUSIP>
        <issuerName>ESSA Pharma Inc.</issuerName>
        <address>
          <com:street1>SUITE 720</com:street1>
          <com:street2>999 WEST BROADWAY</com:street2>
          <com:city>VANCOUVER, BRITISH COLUMBIA</com:city>
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          <personName>JAMES KRATKY</personName>
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            <com:street2>44 Montgomery St., 40th Floor</com:street2>
            <com:city>San Francisco</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>94104</com:zipCode>
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        <notificationInfo>
          <personName>KENNETH A. SCHLESINGER, ESQ.</personName>
          <personPhoneNum>212-451-2300</personPhoneNum>
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            <com:street1>OLSHAN FROME WOLOSKY LLP</com:street1>
            <com:street2>1325 Avenue of the Americas</com:street2>
            <com:city>New York</com:city>
            <com:stateOrCountry>NY</com:stateOrCountry>
            <com:zipCode>10019</com:zipCode>
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        <reportingPersonName>BVF INC/IL</reportingPersonName>
        <memberOfGroup>a</memberOfGroup>
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      </reportingPersonInfo>
      <reportingPersonInfo>
        <reportingPersonCIK>0001233840</reportingPersonCIK>
        <reportingPersonNoCIK>N</reportingPersonNoCIK>
        <reportingPersonName>LAMPERT MARK N</reportingPersonName>
        <memberOfGroup>a</memberOfGroup>
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    </reportingPersons>
    <items1To7>
      <item1>
        <securityTitle>Common Shares</securityTitle>
        <issuerName>ESSA Pharma Inc.</issuerName>
      </item1>
      <item3>
        <fundsSource>Item 3 is hereby amended and restated to read as follows:

As described in Items 4 and 5 below, the Reporting Persons no longer beneficially own any Shares.</fundsSource>
      </item3>
      <item4>
        <transactionPurpose>Item 4 is hereby amended to add the following:

Effective October 9, 2025, the Issuer was acquired by Xeno Acquisition Corp. (the "Purchaser") pursuant to an arrangement under Section 288 of the Business Corporations Act (British Columbia) involving the Issuer, XenoTherapeutics, Inc. (the "Parent"), Purchaser, a wholly-owned subsidiary of Parent, and XOMA Royalty Corporation pursuant to a business combination agreement dated July 13, 2025 and the plan of arrangement, pursuant to which, among other things, the Purchaser acquired all of the outstanding Shares in exchange for: (i) $0.124231 in cash per Share (excluding the approximately $1.69 of cash per Share previously distributed to the Issuer's shareholders) and (ii) one contingent value right per Share for potential cash payments of up to approximately $0.14 per Share.

Accordingly, the Reporting Persons ceased to beneficially own any securities of the Issuer.</transactionPurpose>
      </item4>
      <item5>
        <percentageOfClassSecurities>Item 5(a) is hereby amended and restated to read as follows:

As described in Item 4 above, the Reporting Persons no longer beneficially own any Shares</percentageOfClassSecurities>
        <transactionDesc>Item 5(c) is hereby amended and restated to read as follows:

Except as set forth in Item 4 above, the Reporting Persons have not entered into any transactions in the securities of the Issuer during the past 60 days.</transactionDesc>
        <date5PercentOwnership>Item 5(e) is hereby amended and restated to read as follows:

As of October 9, 2025, the Reporting Persons ceased to be the beneficial owners of more than 5% of the outstanding Shares.</date5PercentOwnership>
      </item5>
    </items1To7>
    <signatureInfo>
      <signaturePerson>
        <signatureReportingPerson>BIOTECHNOLOGY VALUE FUND L P</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
        </signatureDetails>
      </signaturePerson>
      <signaturePerson>
        <signatureReportingPerson>BVF I GP LLC</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
        </signatureDetails>
      </signaturePerson>
      <signaturePerson>
        <signatureReportingPerson>BIOTECHNOLOGY VALUE FUND II LP</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
        </signatureDetails>
      </signaturePerson>
      <signaturePerson>
        <signatureReportingPerson>BVF II GP LLC</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      </signaturePerson>
      <signaturePerson>
        <signatureReportingPerson>Biotechnology Value Trading Fund OS LP</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      </signaturePerson>
      <signaturePerson>
        <signatureReportingPerson>BVF Partners OS Ltd.</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      <signaturePerson>
        <signatureReportingPerson>BVF GP HOLDINGS LLC</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      <signaturePerson>
        <signatureReportingPerson>BVF PARTNERS L P/IL</signatureReportingPerson>
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          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      <signaturePerson>
        <signatureReportingPerson>BVF INC/IL</signatureReportingPerson>
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          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert, Authorized Signatory</title>
          <date>10/14/2025</date>
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      <signaturePerson>
        <signatureReportingPerson>LAMPERT MARK N</signatureReportingPerson>
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          <signature>/s/ Mark N. Lampert</signature>
          <title>Mark N. Lampert</title>
          <date>10/14/2025</date>
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