X0306 4 2021-03-02 0 0001351288 GW PHARMACEUTICALS PLC GWPH 0001633639 Cline Darren S SOVEREIGN HOUSE, VISION PARK, HISTON CAMBRIDGE X0 CB24 9BZ UNITED KINGDOM 0 1 0 0 U.S. Chief Commercial Officer Share Options 0.0014 2021-03-02 4 A 0 75024 0.00 A Ordinary Shares 75024 75024 D Share Options 0.0014 2021-03-02 4 A 0 46896 0.00 A Ordinary Shares 46896 46896 D Granted pursuant to the Issuer's Long-Term Incentive Plan. These share options will vest and be automatically exercised on February 22, 2024 if certain performance conditions are satisfied. Converted from British Pounds Sterling to U.S. Dollars using currency ratio of 1.00 British Pound Sterling = 1.41 U.S. Dollars as of February 22, 2021. Granted pursuant to the Issuer's Long-Term Incentive Plan. These share options will vest in four equal annual installments beginning on February 22, 2022 and be automatically exercised upon vesting. Subject to accelerated vesting in connection with the closing of the transactions contemplated by the Transaction Agreement, dated as of February 3, 2021, by and among Jazz Pharmaceuticals UK Holdings Limited, Jazz Pharmaceuticals Public Limited Company and GW Pharmaceuticals plc. The share numbers underlying options granted on February 22, 2021 and reported on the reporting person's form 4 filed on February 24, 2021 were amended as of March 2, 2021 and as reported in this form 4. /s/ Darren S. Cline 2021-03-04