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    <nameOfIssuer>AGENUS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>00847G705</cusip>
    <value>7953</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2439554</sshPrnamt>
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      <Sole>2439554</Sole>
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      <None>0</None>
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    <nameOfIssuer>ALIMERA SCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>016259103</cusip>
    <value>8301</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6241581</sshPrnamt>
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      <Sole>6241581</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03152W109</cusip>
    <value>104516</value>
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      <sshPrnamt>7263122</sshPrnamt>
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      <Sole>7263122</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03152W109</cusip>
    <value>1763</value>
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      <sshPrnamt>1500000</sshPrnamt>
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    <putCall>Call</putCall>
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    <votingAuthority>
      <Sole>1500000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>APELLIS PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03753U106</cusip>
    <value>7316</value>
    <shrsOrPrnAmt>
      <sshPrnamt>396635</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>396635</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ARGENX SE</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>04016X101</cusip>
    <value>50820</value>
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      <sshPrnamt>804875</sshPrnamt>
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    <votingAuthority>
      <Sole>804875</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>69991</value>
    <shrsOrPrnAmt>
      <sshPrnamt>5468029</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>5468029</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>216</value>
    <shrsOrPrnAmt>
      <sshPrnamt>75000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>75000</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ASCENDIS PHARMA</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>04351P101</cusip>
    <value>67342</value>
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      <sshPrnamt>1681024</sshPrnamt>
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      <Sole>1681024</Sole>
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      <None>0</None>
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    <nameOfIssuer>ASSEMBLY BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>045396108</cusip>
    <value>48351</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1068534</sshPrnamt>
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    <votingAuthority>
      <Sole>1068534</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ASTRAZENECA PLC</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>046353108</cusip>
    <value>26035</value>
    <shrsOrPrnAmt>
      <sshPrnamt>750300</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>750300</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AVEO PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>053588109</cusip>
    <value>11179</value>
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      <sshPrnamt>4006893</sshPrnamt>
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      <Sole>4006893</Sole>
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      <None>0</None>
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    <nameOfIssuer>AVEXIS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>05366U100</cusip>
    <value>65983</value>
    <shrsOrPrnAmt>
      <sshPrnamt>596217</sshPrnamt>
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      <Sole>596217</Sole>
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      <None>0</None>
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    <nameOfIssuer>BIOCRYST PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09058V103</cusip>
    <value>1673</value>
    <shrsOrPrnAmt>
      <sshPrnamt>340821</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>340821</Sole>
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      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BIODELIVERY SCIENCE INTL</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09060J106</cusip>
    <value>7285</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2469488</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2469488</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BIOMARIN PHARMACEUTICAL INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09061G101</cusip>
    <value>106070</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1189524</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1189524</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BIOMARIN PHARMACEUTICAL INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09061G101</cusip>
    <value>135</value>
    <shrsOrPrnAmt>
      <sshPrnamt>300000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>300000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BRISTOL MYERS SQUIBB CO</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>110122108</cusip>
    <value>27957</value>
    <shrsOrPrnAmt>
      <sshPrnamt>456223</sshPrnamt>
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    <votingAuthority>
      <Sole>456223</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CASCADIAN THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>14740B606</cusip>
    <value>9196</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2485272</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2485272</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CATALYST BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>14888D208</cusip>
    <value>5456</value>
    <shrsOrPrnAmt>
      <sshPrnamt>400000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>400000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CATALYST PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>14888U101</cusip>
    <value>15219</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3892343</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3892343</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>CELLECTIS S A</nameOfIssuer>
    <titleOfClass>Sponsored ADS</titleOfClass>
    <cusip>15117K103</cusip>
    <value>2282</value>
    <shrsOrPrnAmt>
      <sshPrnamt>78289</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>78289</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CLOVIS ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>189464100</cusip>
    <value>74996</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1102884</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1102884</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CLOVIS ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>189464100</cusip>
    <value>41</value>
    <shrsOrPrnAmt>
      <sshPrnamt>150000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>150000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CLOVIS ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>189464100</cusip>
    <value>223</value>
    <shrsOrPrnAmt>
      <sshPrnamt>525000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
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    <votingAuthority>
      <Sole>525000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>DERMIRA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>24983L104</cusip>
    <value>42271</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1520000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1520000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>FENNEC PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>31447P100</cusip>
    <value>2726</value>
    <shrsOrPrnAmt>
      <sshPrnamt>206000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>206000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>GLOBAL BLOOD THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>37890U108</cusip>
    <value>72479</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1841896</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1841896</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>HORIZON PHARMA PLC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>G4617B105</cusip>
    <value>64768</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4436183</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4436183</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IMMUNOMEDICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>452907108</cusip>
    <value>8225</value>
    <shrsOrPrnAmt>
      <sshPrnamt>875000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>875000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>IMMUNOMEDICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>452907108</cusip>
    <value>259602</value>
    <shrsOrPrnAmt>
      <sshPrnamt>16064461</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>16064461</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>INCYTE CORP</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>45337C102</cusip>
    <value>4736</value>
    <shrsOrPrnAmt>
      <sshPrnamt>50000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>50000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>INTEC PHARMA LTD</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>M53644106</cusip>
    <value>11308</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2195705</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2195705</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IOVANCE BIOTHERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>462260100</cusip>
    <value>42028</value>
    <shrsOrPrnAmt>
      <sshPrnamt>5253450</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>5253450</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MEDICINES CO</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>584688105</cusip>
    <value>35448</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1296560</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1296560</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MACROGENICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>556099109</cusip>
    <value>31</value>
    <shrsOrPrnAmt>
      <sshPrnamt>11400</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>11400</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MACROGENICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>556099109</cusip>
    <value>6</value>
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      <sshPrnamt>3100</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3100</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MIRATI THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>60468T105</cusip>
    <value>80265</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4398101</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4398101</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>MYOKARDIA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>62857M105</cusip>
    <value>16765</value>
    <shrsOrPrnAmt>
      <sshPrnamt>398207</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
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