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    <nameOfIssuer>ACADIA PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>004225108</cusip>
    <value>56039</value>
    <shrsOrPrnAmt>
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    <votingAuthority>
      <Sole>1630000</Sole>
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      <None>0</None>
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    <nameOfIssuer>AERIE PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>00771V108</cusip>
    <value>19274</value>
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      <sshPrnamt>425000</sshPrnamt>
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    <votingAuthority>
      <Sole>425000</Sole>
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      <None>0</None>
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    <nameOfIssuer>AGENUS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>00847G705</cusip>
    <value>12700</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3368828</sshPrnamt>
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      <Sole>3368828</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AKEBIA THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>00972D105</cusip>
    <value>4199</value>
    <shrsOrPrnAmt>
      <sshPrnamt>456369</sshPrnamt>
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    <votingAuthority>
      <Sole>456369</Sole>
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    <nameOfIssuer>ALIMERA SCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>016259103</cusip>
    <value>8108</value>
    <shrsOrPrnAmt>
      <sshPrnamt>5791581</sshPrnamt>
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    <votingAuthority>
      <Sole>5791581</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03152W109</cusip>
    <value>34563</value>
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      <sshPrnamt>4847577</sshPrnamt>
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      <Sole>4847577</Sole>
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      <None>0</None>
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    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03152W109</cusip>
    <value>206</value>
    <shrsOrPrnAmt>
      <sshPrnamt>250000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>250000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>33793</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3780000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>3780000</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>121</value>
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      <sshPrnamt>161400</sshPrnamt>
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    <putCall>Call</putCall>
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      <Sole>161400</Sole>
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      <None>0</None>
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  <infoTable>
    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>120</value>
    <shrsOrPrnAmt>
      <sshPrnamt>300000</sshPrnamt>
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    <votingAuthority>
      <Sole>300000</Sole>
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      <None>0</None>
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    <nameOfIssuer>ARRAY BIOPHARMA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>04269X105</cusip>
    <value>149</value>
    <shrsOrPrnAmt>
      <sshPrnamt>400000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>400000</Sole>
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      <None>0</None>
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    <nameOfIssuer>ASCENDIS PHARMA</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>04351P101</cusip>
    <value>19626</value>
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      <Sole>700924</Sole>
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      <None>0</None>
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    <nameOfIssuer>ASSEMBLY BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>045396108</cusip>
    <value>17751</value>
    <shrsOrPrnAmt>
      <sshPrnamt>696409</sshPrnamt>
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    <votingAuthority>
      <Sole>696409</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AVEO PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>053588109</cusip>
    <value>2323</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3938030</sshPrnamt>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3938030</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AVEXIS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>05366U100</cusip>
    <value>17135</value>
    <shrsOrPrnAmt>
      <sshPrnamt>225370</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>225370</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>AXOVANT SCIENCES LTD</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>G0750W104</cusip>
    <value>5746</value>
    <shrsOrPrnAmt>
      <sshPrnamt>384587</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>384587</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BELLICUM PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>079481107</cusip>
    <value>1543</value>
    <shrsOrPrnAmt>
      <sshPrnamt>125000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>125000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BIOCRYST PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09058V103</cusip>
    <value>13465</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1603001</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1603001</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BIOMARIN PHARMACEUTICAL INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09061G101</cusip>
    <value>51790</value>
    <shrsOrPrnAmt>
      <sshPrnamt>590000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>590000</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>BLUEPRINT MEDICINES CORP</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>09627Y109</cusip>
    <value>6598</value>
    <shrsOrPrnAmt>
      <sshPrnamt>165000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>165000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CASCADIAN THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>14740B606</cusip>
    <value>7540</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1821248</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1821248</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>CATALYST PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>14888U101</cusip>
    <value>7419</value>
    <shrsOrPrnAmt>
      <sshPrnamt>3804745</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>3804745</Sole>
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      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CELLECTIS - ADR</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>15117K103</cusip>
    <value>2330</value>
    <shrsOrPrnAmt>
      <sshPrnamt>97096</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>97096</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CLOVIS ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>189464100</cusip>
    <value>22533</value>
    <shrsOrPrnAmt>
      <sshPrnamt>353900</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>353900</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CLOVIS ONCOLOGY INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>189464100</cusip>
    <value>258</value>
    <shrsOrPrnAmt>
      <sshPrnamt>125800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <putCall>Call</putCall>
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    <votingAuthority>
      <Sole>125800</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CORVUS PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>221015100</cusip>
    <value>2528</value>
    <shrsOrPrnAmt>
      <sshPrnamt>121715</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>121715</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>DERMIRA INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>24983L104</cusip>
    <value>41011</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1202313</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1202313</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>FORTRESS BIOTECH INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>34960Q109</cusip>
    <value>3688</value>
    <shrsOrPrnAmt>
      <sshPrnamt>996663</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>996663</Sole>
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      <None>0</None>
    </votingAuthority>
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    <nameOfIssuer>GLOBAL BLOOD THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>37890U108</cusip>
    <value>30033</value>
    <shrsOrPrnAmt>
      <sshPrnamt>815000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>815000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IMMUNOMEDICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>452907108</cusip>
    <value>67858</value>
    <shrsOrPrnAmt>
      <sshPrnamt>10488076</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>10488076</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>LION BIOTECHNOLOGIES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>53619R102</cusip>
    <value>33908</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4551343</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4551343</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MEDICINES CO</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>584688105</cusip>
    <value>57947</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1185000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1185000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MIRATI THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>60468T105</cusip>
    <value>12393</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2383201</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2383201</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>NEURODERM LTD</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>M74231107</cusip>
    <value>15665</value>
    <shrsOrPrnAmt>
      <sshPrnamt>590000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>590000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ONCOBIOLOGICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>68235M105</cusip>
    <value>1832</value>
    <shrsOrPrnAmt>
      <sshPrnamt>683531</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>683531</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ONCOBIOLOGICS INC - WARRANT A</nameOfIssuer>
    <titleOfClass>Warrant</titleOfClass>
    <cusip>68235M113</cusip>
    <value>187</value>
    <shrsOrPrnAmt>
      <sshPrnamt>233333</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>233333</Sole>
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      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ONCOBIOLOGICS INC - WARRANT B</nameOfIssuer>
    <titleOfClass>Warrant</titleOfClass>
    <cusip>68235M121</cusip>
    <value>117</value>
    <shrsOrPrnAmt>
      <sshPrnamt>233333</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>233333</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>PACIRA PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>695127100</cusip>
    <value>18696</value>
    <shrsOrPrnAmt>
      <sshPrnamt>410000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>410000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>PERNIX THERAPEUTICS HOLDINGS INC</nameOfIssuer>
    <titleOfClass>Convertible Debt</titleOfClass>
    <cusip>71426VAK4</cusip>
    <value>1651</value>
    <shrsOrPrnAmt>
      <sshPrnamt>6000000</sshPrnamt>
      <sshPrnamtType>PRN</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>6000000</Sole>
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