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  <infoTable>
    <nameOfIssuer>AGENUS - INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>00847G705</cusip>
    <value>10506</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2047971</sshPrnamt>
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    <votingAuthority>
      <Sole>2047971</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>ALIMERA SCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>016259103</cusip>
    <value>408</value>
    <shrsOrPrnAmt>
      <sshPrnamt>81372</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
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    <votingAuthority>
      <Sole>81372</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>AMICUS THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>03152W109</cusip>
    <value>45820</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4211399</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <votingAuthority>
      <Sole>4211399</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BELLICUM PHARMACEUTICALS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>079481107</cusip>
    <value>11006</value>
    <shrsOrPrnAmt>
      <sshPrnamt>475015</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>475015</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>BIOLASE INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>090911108</cusip>
    <value>1394</value>
    <shrsOrPrnAmt>
      <sshPrnamt>690000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>690000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CELGENE CORP.</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>151020904</cusip>
    <value>17154</value>
    <shrsOrPrnAmt>
      <sshPrnamt>148800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>148800</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CELLECTIS</nameOfIssuer>
    <titleOfClass>Sponsored ADS</titleOfClass>
    <cusip>15117K103</cusip>
    <value>1037</value>
    <shrsOrPrnAmt>
      <sshPrnamt>30000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>30000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CHEMOCENTRYX - INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>16383L106</cusip>
    <value>2443</value>
    <shrsOrPrnAmt>
      <sshPrnamt>323607</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>323607</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>CORONADO BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>21976U109</cusip>
    <value>2310</value>
    <shrsOrPrnAmt>
      <sshPrnamt>600000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>600000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EMERGENT BIOSOLUTIONS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>29089Q105</cusip>
    <value>9509</value>
    <shrsOrPrnAmt>
      <sshPrnamt>330635</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>330635</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>EXELIXIS INC EXEL 20190815 4.250000%</nameOfIssuer>
    <titleOfClass>Notes</titleOfClass>
    <cusip>30161QAC8</cusip>
    <value>3234</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4250000</sshPrnamt>
      <sshPrnamtType>PRN</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4250000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>FLAMEL TECHNOLOGIES</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>338488109</cusip>
    <value>3878</value>
    <shrsOrPrnAmt>
      <sshPrnamt>215705</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>215705</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>HEAT BIOLOGICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>42237K102</cusip>
    <value>1654</value>
    <shrsOrPrnAmt>
      <sshPrnamt>260000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>260000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IGI LABORATORIES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>449575109</cusip>
    <value>5883</value>
    <shrsOrPrnAmt>
      <sshPrnamt>720908</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>720908</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>IGNYTA INC.</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>451731103</cusip>
    <value>1998</value>
    <shrsOrPrnAmt>
      <sshPrnamt>200772</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>200772</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>INNOCOLL AG</nameOfIssuer>
    <titleOfClass>Sponsored ADR</titleOfClass>
    <cusip>45780Q103</cusip>
    <value>1689</value>
    <shrsOrPrnAmt>
      <sshPrnamt>225000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>225000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>LA JOLLA PHARMACEUTICAL CO.</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>503459604</cusip>
    <value>8445</value>
    <shrsOrPrnAmt>
      <sshPrnamt>461499</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>461499</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>LION BIOTECHNOLOGIES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>53619R102</cusip>
    <value>26035</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2149907</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2149907</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>MIRATI THERAPEUTICS INC.</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>60468T105</cusip>
    <value>9408</value>
    <shrsOrPrnAmt>
      <sshPrnamt>320867</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>320867</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>ONCOTHYREON INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>682324108</cusip>
    <value>7321</value>
    <shrsOrPrnAmt>
      <sshPrnamt>4491636</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>4491636</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>PERNIX THERAPEUTICS HOLDINGS</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>71426V108</cusip>
    <value>14914</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1395167</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1395167</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>RECEPTOS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>756207106</cusip>
    <value>7255</value>
    <shrsOrPrnAmt>
      <sshPrnamt>44000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>44000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SANGAMO BIOSCIENCES INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>800677106</cusip>
    <value>3829</value>
    <shrsOrPrnAmt>
      <sshPrnamt>244199</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>244199</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>SORRENTO THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>83587F202</cusip>
    <value>25594</value>
    <shrsOrPrnAmt>
      <sshPrnamt>2214043</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>2214043</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>STEMLINE THERAPEUTICS - INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>85858C107</cusip>
    <value>6873</value>
    <shrsOrPrnAmt>
      <sshPrnamt>475000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>475000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>TARGACEPT INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>87611R306</cusip>
    <value>1385</value>
    <shrsOrPrnAmt>
      <sshPrnamt>466297</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>466297</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>TARO PHARMACEUTICAL INDUS</nameOfIssuer>
    <titleOfClass>Shares</titleOfClass>
    <cusip>M8737E108</cusip>
    <value>7587</value>
    <shrsOrPrnAmt>
      <sshPrnamt>53800</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>53800</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>THERAPEUTICS MD INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>88338N107</cusip>
    <value>2372</value>
    <shrsOrPrnAmt>
      <sshPrnamt>392000</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>392000</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
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  <infoTable>
    <nameOfIssuer>TONIX PHARMACEUTICALS HLDG</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>890260201</cusip>
    <value>4773</value>
    <shrsOrPrnAmt>
      <sshPrnamt>755300</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>755300</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>TRILLIUM THERAPEUTICS INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>89620X506</cusip>
    <value>3234</value>
    <shrsOrPrnAmt>
      <sshPrnamt>160697</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>160697</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>TROVAGENE INC</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>897238309</cusip>
    <value>2205</value>
    <shrsOrPrnAmt>
      <sshPrnamt>323728</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>323728</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>UNIQURE N V</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>N90064101</cusip>
    <value>5507</value>
    <shrsOrPrnAmt>
      <sshPrnamt>226456</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
    </shrsOrPrnAmt>
    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>226456</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
  <infoTable>
    <nameOfIssuer>VERICEL CORP.</nameOfIssuer>
    <titleOfClass>Common</titleOfClass>
    <cusip>92346J108</cusip>
    <value>3918</value>
    <shrsOrPrnAmt>
      <sshPrnamt>1058820</sshPrnamt>
      <sshPrnamtType>SH</sshPrnamtType>
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    <investmentDiscretion>SOLE</investmentDiscretion>
    <votingAuthority>
      <Sole>1058820</Sole>
      <Shared>0</Shared>
      <None>0</None>
    </votingAuthority>
  </infoTable>
</informationTable>
