0001104659-26-061754.txt : 20260515 0001104659-26-061754.hdr.sgml : 20260515 20260515065312 ACCESSION NUMBER: 0001104659-26-061754 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20260331 FILED AS OF DATE: 20260515 DATE AS OF CHANGE: 20260515 EFFECTIVENESS DATE: 20260515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Avoro Capital Advisors LLC CENTRAL INDEX KEY: 0001633313 ORGANIZATION NAME: EIN: 271007403 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-16573 FILM NUMBER: 26982076 BUSINESS ADDRESS: STREET 1: 110 GREENE STREET STREET 2: SUITE 800 CITY: NEW YORK STATE: NY ZIP: 10012 BUSINESS PHONE: 212-937-4975 MAIL ADDRESS: STREET 1: 110 GREENE STREET STREET 2: SUITE 800 CITY: NEW YORK STATE: NY ZIP: 10012 FORMER COMPANY: FORMER CONFORMED NAME: venBio Select Advisor LLC DATE OF NAME CHANGE: 20150210 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE false false false 0001633313 XXXXXXXX 03-31-2026 03-31-2026 false Avoro Capital Advisors LLC

110 Greene Street Suite 800 New York NY 10012

13F HOLDINGS REPORT 028-16573 000154091 801-74391 N Scott Epstein 212-937-4975 /s/ Scott Epstein New York NY 05-15-2026 0 33 10164789055 INFORMATION TABLE 2 infotable.xml ALKERMES PLC Common G01767105 42432000 1200000 SH SOLE 1200000 0 0 APELLIS PHARMACEUTICALS INC Common 03753U106 491699991 12222222 SH SOLE 12222222 0 0 ARGENX SE Sponsored ADR 04016X101 730250000 1000000 SH SOLE 1000000 0 0 ARROWHEAD PHARMACEUTICALS INC Common 04280A100 670889937 10699999 SH SOLE 10699999 0 0 ASCENDIS PHARMA Sponsored ADR 04351P101 1157945625 5062500 SH SOLE 5062500 0 0 AVALO THERAPEUTICS Common 05338F306 21051300 1410000 SH SOLE 1410000 0 0 CELCUITY INC Common 15102K100 3050000 200000 SH Call SOLE 200000 0 0 CELCUITY INC Common 15102K100 385222500 3375000 SH SOLE 3375000 0 0 CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100 454017673 11430455 SH SOLE 11430455 0 0 CYTOKINETICS INC Common 23282W605 219699978 3333333 SH SOLE 3333333 0 0 DAMORA THERAPEUTICS INC Common 36322Q206 97979700 3783000 SH SOLE 3783000 0 0 DEFINIUM THERAPEUTICS INC Common 24477V105 94500000 5000000 SH SOLE 5000000 0 0 GH RESEARCH PLC ORDINARY SHARES G3855L106 25308000 1800000 SH SOLE 1800000 0 0 KRYSTAL BIOTECH INC Common 501147102 746257548 2888888 SH SOLE 2888888 0 0 KYMERA THERAPEUTICS INC Common 501575104 622571678 7474747 SH SOLE 7474747 0 0 LEXEO THERAPEUTICS INC Common 52886X107 10762500 1875000 SH SOLE 1875000 0 0 MADRIGAL PHARMACEUTICALS INC Common 558868105 951763208 1818181 SH SOLE 1818181 0 0 MANNKIND CORP Common 56400P706 5390000 2200000 SH SOLE 2200000 0 0 OCULAR THERAPEUTIX INC Common 67576A100 104308050 12315000 SH SOLE 12315000 0 0 REVOLUTION MEDICINES INC Common 76155X100 227997179 2344444 SH SOLE 2344444 0 0 SEPTERNA INC Common 81734D104 32140125 1337500 SH SOLE 1337500 0 0 SOLENO THERAPEUTICS INC Common 834203309 77004000 2300000 SH SOLE 2300000 0 0 STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106 315977751 6555555 SH SOLE 6555555 0 0 TAYSHA GENE THERAPIES INC Common 877619106 96999000 21700000 SH SOLE 21700000 0 0 TERNS PHARMACEUTICALS INC Common 880881107 300240400 5695000 SH SOLE 5695000 0 0 UNIQURE NV Common N90064101 97439378 5959595 SH SOLE 5959595 0 0 UNITED THERAPEUTICS CORP Common 91307C102 1559537400 2630000 SH SOLE 2630000 0 0 UNITED THERAPEUTICS CORP Common 91307C102 5688000 200000 SH Call SOLE 200000 0 0 UNITED THERAPEUTICS CORP Common 91307C102 4608000 180000 SH Call SOLE 180000 0 0 VERA THERAPEUTICS INC Common 92337R101 236909964 5888888 SH SOLE 5888888 0 0 VIRIDIAN THERAPEUTICS INC Common 92790C104 29340000 1500000 SH SOLE 1500000 0 0 WHITEHAWK THERAPEUTICS INC Common 00032Q104 9830437 2849402 SH SOLE 2849402 0 0 XENON PHARMACEUTICALS INC Common 98420N105 335977733 5777777 SH SOLE 5777777 0 0