The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC Common 282559103   46,164,500 6,350,000 SH   SOLE   6,350,000 0 0
ALKERMES PLC Common G01767105   80,899,000 2,450,000 SH   SOLE   2,450,000 0 0
AMICUS THERAPEUTICS INC. Common 03152W109   167,280,000 20,500,000 SH   SOLE   20,500,000 0 0
APELLIS PHARMACEUTICALS INC. Common 03753U106   267,299,995 12,222,222 SH   SOLE   12,222,222 0 0
ARGENX SE Sponsored ADR 04016X101   731,058,035 1,235,177 SH   SOLE   1,235,177 0 0
ARROWHEAD PHARMACEUTICALS INC. Common 04280A100   141,555,554 11,111,111 SH   SOLE   11,111,111 0 0
ASCENDIS PHARMA Sponsored ADR 04351P101   813,277,480 5,218,000 SH   SOLE   5,218,000 0 0
AUTOLUS THERAPEUTICS PLC Sponsored ADR 05280R100   15,361,495 9,910,642 SH   SOLE   9,910,642 0 0
AVIDITY BIOSCIENCES INC Common 05370A108   225,090,000 7,625,000 SH   SOLE   7,625,000 0 0
BIOCRYST PHARMACEUTICALS INC Common 09058V103   65,250,000 8,700,000 SH   SOLE   8,700,000 0 0
BLUEPRINT MEDICINES CORP Common 09627Y109   340,763,500 3,850,000 SH   SOLE   3,850,000 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADR 152309100   58,239,000 4,050,000 SH   SOLE   4,050,000 0 0
INTRA-CELLULAR THERAPIES INC Common 46116X101   82,450,000 625,000 SH   SOLE   625,000 0 0
KRYSTAL BIOTECH INC Common 501147102   492,399,300 2,731,000 SH   SOLE   2,731,000 0 0
KYMERA THERAPEUTICS INC Common 501575104   176,810,200 6,460,000 SH   SOLE   6,460,000 0 0
MADRIGAL PHARMACEUTICALS INC Common 558868105   669,820,593 2,022,222 SH   SOLE   2,022,222 0 0
MANNKIND CORP Common 56400P706   44,012,500 8,750,000 SH   SOLE   8,750,000 0 0
MERUS N V Common N5749R100   126,270,000 3,000,000 SH   SOLE   3,000,000 0 0
MONTE ROSA THERAPEUTICS INC Common 61225M102   21,555,343 4,645,548 SH   SOLE   4,645,548 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   108,227,807 2,770,100 SH   SOLE   2,770,100 0 0
OCULAR THERAPEUTIX INC Common 67576A100   59,079,800 8,060,000 SH   SOLE   8,060,000 0 0
SAREPTA THERAPEUTICS INC Common 803607100   170,707,970 2,674,835 SH   SOLE   2,674,835 0 0
SEPTERNA INC Common 81734D104   7,744,125 1,337,500 SH   SOLE   1,337,500 0 0
SOLENO THERAPEUTICS INC Common 834203309   180,411,250 2,525,000 SH   SOLE   2,525,000 0 0
TAYSHA GENE THERAPIES INC Common 877619106   27,799,999 19,999,999 SH   SOLE   19,999,999 0 0
TOURMALINE BIO INC Common 89157D105   36,884,250 2,425,000 SH   SOLE   2,425,000 0 0
ULTRAGENYX PHARMACEUTICAL INC Common 90400D108   30,054,300 830,000 SH   SOLE   830,000 0 0
UNIQURE NV Common N90064101   23,055,000 2,175,000 SH   SOLE   2,175,000 0 0
UNITED THERAPEUTICS CORP Common 91307C102   824,622,250 2,675,000 SH   SOLE   2,675,000 0 0
VAXCYTE INC Common 92243G108   37,760,000 1,000,000 SH   SOLE   1,000,000 0 0
VERA THERAPEUTICS INC Common 92337R101   136,959,638 5,701,900 SH   SOLE   5,701,900 0 0
WHITEHAWK THERAPEUTICS INC Common 00032Q104   5,071,936 2,849,402 SH   SOLE   2,849,402 0 0
XENON PHARMACEUTICALS INC Common 98420N105   192,632,894 5,741,666 SH   SOLE   5,741,666 0 0