The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AADI BIOSCIENCES INC | Common | 00032Q104 | 53,730 | 1,829,402 | SH | SOLE | 1,829,402 | 0 | 0 | ||
| ACADIA PHARMACEUTICALS INC | Common | 004225108 | 36,542 | 2,200,000 | SH | SOLE | 2,200,000 | 0 | 0 | ||
| ACCELERON PHARMA INC | Common | 00434H108 | 688,400 | 4,000,000 | SH | SOLE | 4,000,000 | 0 | 0 | ||
| ACCELERON PHARMA INC | Common | 00434H108 | 10 | 41,700 | SH | Call | SOLE | 41,700 | 0 | 0 | |
| ACCELERON PHARMA INC | Common | 00434H108 | 22 | 434,400 | SH | Call | SOLE | 434,400 | 0 | 0 | |
| ADVERUM BIOTECHNOLOGIES INC | Common | 00773U108 | 15,082 | 6,950,000 | SH | SOLE | 6,950,000 | 0 | 0 | ||
| ALNYLAM PHARMACEUTICALS INC | Common | 02043Q107 | 160,489 | 850,000 | SH | SOLE | 850,000 | 0 | 0 | ||
| AMARIN CORP PLC | Sponsored ADR | 023111206 | 30,600 | 6,000,000 | SH | SOLE | 6,000,000 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | Common | 03152W109 | 168,837 | 17,679,273 | SH | SOLE | 17,679,273 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | Common | 03753U106 | 164,800 | 5,000,000 | SH | SOLE | 5,000,000 | 0 | 0 | ||
| APELLIS PHARMACEUTICALS INC | Common | 03753U106 | 142 | 150,000 | SH | Call | SOLE | 150,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | Common | 03753U106 | 96 | 240,000 | SH | Call | SOLE | 240,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | Common | 03753U106 | 38 | 750,000 | SH | Call | SOLE | 750,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | Common | 03753U106 | 984 | 375,000 | SH | Call | SOLE | 375,000 | 0 | 0 | |
| ARENA PHARMACEUTICALS INC | Common | 040047607 | 203,959 | 3,425,000 | SH | SOLE | 3,425,000 | 0 | 0 | ||
| ARGENX SE | Sponsored ADR | 04016X101 | 285,843 | 946,500 | SH | SOLE | 946,500 | 0 | 0 | ||
| ASCENDIS PHARMA | Sponsored ADR | 04351P101 | 315,592 | 1,980,000 | SH | SOLE | 1,980,000 | 0 | 0 | ||
| AVADEL PHARMACEUTICALS PLC | Sponsored ADR | 05337M104 | 22,295 | 2,275,000 | SH | SOLE | 2,275,000 | 0 | 0 | ||
| AVIDITY BIOSCIENCES INC | Common | 05370A108 | 28,325 | 1,150,000 | SH | SOLE | 1,150,000 | 0 | 0 | ||
| BIOGEN INC | Common | 09062X103 | 23,771 | 84,000 | SH | SOLE | 84,000 | 0 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | Common | 09061G101 | 144,919 | 1,875,000 | SH | SOLE | 1,875,000 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | Common | 23257D103 | 37,595 | 10,300,000 | SH | SOLE | 10,300,000 | 0 | 0 | ||
| DECIPHERA PHARMACEUTICALS INC | Common | 24344T101 | 36,291 | 1,068,000 | SH | SOLE | 1,068,000 | 0 | 0 | ||
| DESIGN THERAPEUTICS INC | Common | 25056L103 | 21,570 | 1,468,318 | SH | SOLE | 1,468,318 | 0 | 0 | ||
| DICE THERAPEUTICS INC | Common | 23345J104 | 26,200 | 800,000 | SH | SOLE | 800,000 | 0 | 0 | ||
| FENNEC PHARMACEUTICALS INC | Common | 31447P100 | 15,731 | 1,670,000 | SH | SOLE | 1,670,000 | 0 | 0 | ||
| GENOCEA BIOSCIENCES INC | Common | 372427401 | 9,762 | 5,084,184 | SH | SOLE | 5,084,184 | 0 | 0 | ||
| HORIZON THERAPEUTICS PLC | Common | G46188101 | 985,860 | 9,000,000 | SH | SOLE | 9,000,000 | 0 | 0 | ||
| IOVANCE BIOTHERAPEUTICS INC | Common | 462260100 | 595 | 350,000 | SH | Call | SOLE | 350,000 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | Common | 462260100 | 945 | 300,000 | SH | Call | SOLE | 300,000 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | Common | 462260100 | 209,610 | 8,500,000 | SH | SOLE | 8,500,000 | 0 | 0 | ||
| IVERIC BIO INC | Common | 46583P102 | 115,304 | 7,100,000 | SH | SOLE | 7,100,000 | 0 | 0 | ||
| KURA ONCOLOGY INC | Common | 50127T109 | 74,920 | 4,000,000 | SH | SOLE | 4,000,000 | 0 | 0 | ||
| KYMERA THERAPEUTICS INC | Common | 501575104 | 26,771 | 455,750 | SH | SOLE | 455,750 | 0 | 0 | ||
| MADRIGAL PHARMACEUTICALS INC | Common | 558868105 | 113,701 | 1,425,000 | SH | SOLE | 1,425,000 | 0 | 0 | ||
| MANNKIND CORP | Common | 56400P706 | 38,280 | 8,800,000 | SH | SOLE | 8,800,000 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | Common | 56854Q200 | 36,814 | 3,235,000 | SH | SOLE | 3,235,000 | 0 | 0 | ||
| MERSANA THERAPEUTICS INC | Common | 59045L106 | 64,124 | 6,800,000 | SH | SOLE | 6,800,000 | 0 | 0 | ||
| MERUS N V | Common | N5749R100 | 9,900 | 450,000 | SH | SOLE | 450,000 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | Common | 60468T105 | 884,550 | 5,000,000 | SH | SOLE | 5,000,000 | 0 | 0 | ||
| MONTE ROSA THERAPEUTICS INC | Common | 61225M102 | 61,003 | 3,311,434 | SH | SOLE | 3,311,434 | 0 | 0 | ||
| NUVALENT INC | Common | 670703107 | 22,288 | 1,257,671 | SH | SOLE | 1,257,671 | 0 | 0 | ||
| PMV PHARMACEUTICALS INC | Common | 69353Y103 | 87,165 | 2,925,000 | SH | SOLE | 2,925,000 | 0 | 0 | ||
| PRAXIS PRECISION MEDICINES INC | Common | 74006W108 | 29,584 | 1,600,000 | SH | SOLE | 1,600,000 | 0 | 0 | ||
| SAREPTA THERAPEUTICS INC | Common | 803607100 | 231,200 | 2,500,000 | SH | SOLE | 2,500,000 | 0 | 0 | ||
| SAREPTA THERAPEUTICS INC | Common | 803607100 | 2,194 | 200,000 | SH | Call | SOLE | 200,000 | 0 | 0 | |
| SYNDAX PHARMACEUTICALS INC | Common | 87164F105 | 29,525 | 1,545,000 | SH | SOLE | 1,545,000 | 0 | 0 | ||
| TANGO THERAPEUTICS INC | Common | 87583X109 | 20,042 | 1,550,000 | SH | SOLE | 1,550,000 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | Common | 89620X506 | 100,092 | 5,700,000 | SH | SOLE | 5,700,000 | 0 | 0 | ||
| UNITED THERAPEUTICS CORP | Common | 91307C102 | 553,740 | 3,000,000 | SH | SOLE | 3,000,000 | 0 | 0 | ||
| VERTEX PHARMACEUTICALS INC | Common | 92532F100 | 120,443 | 664,000 | SH | SOLE | 664,000 | 0 | 0 | ||
| XENON PHARMACEUTICALS INC | Common | 98420N105 | 55,772 | 3,650,000 | SH | SOLE | 3,650,000 | 0 | 0 | ||