SCHEDULE 13G/A 0000902664-24-001592 0001633313 XXXXXXXX LIVE 1 Common Stock, $0.01 par value 03/31/2025 0000882796 BIOCRYST PHARMACEUTICALS INC 09058V103 4505 EMPEROR BOULEVARD SUITE 200 DURHAM NC 27703 Rule 13d-1(b) Avoro Capital Advisors LLC b DE 8700000.00 0.00 8700000.00 0.00 8700000.00 N 4.2 IA OO Behzad Aghazadeh b X1 8700000.00 0.00 8700000.00 0.00 8700000.00 N 4.2 HC IN BIOCRYST PHARMACEUTICALS INC 4505 Emperor Blvd., Suite 200, Durham, North Carolina 27703 This statement is filed by: (i) Avoro Capital Advisors LLC, a Delaware limited liability company ("Avoro"), which provides investment advisory and management services and has acquired the shares of common stock, par value $0.01 per share ("Common Stock") of BioCryst Pharmaceuticals Inc., a Delaware corporation (the "Issuer"), solely for investment purposes on behalf of Avoro Life Sciences Fund LLC, a Delaware limited liability company, and (ii) Behzad Aghazadeh ("Dr. Aghazadeh," and together with Avoro, the "Reporting Persons"), who serves as the portfolio manager and controlling person of Avoro. The filing of this statement should not be construed as an admission that any Reporting Person is, for purposes of Section 13 of the Act, the beneficial owner of the securities reported herein. The address of the business office of each of the Reporting Persons is 110 Greene Street, Suite 800, New York, NY 10012. Avoro is a Delaware limited liability company. Dr. Aghazadeh is a United States citizen. N IA HC The information required by Item 4(a) is set forth in Row 9 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The percentage set forth in this Schedule 13G is calculated based upon 208,960,020 shares of Common Stock outstanding as of February 20, 2025, as reported in the Issuer's Annual Report on Form 10-K for the year ended December 31, 2024, filed with the Securities and Exchange Commission on February 25, 2025. 4.2% The information required by Item 4(c)(i) is set forth in Row 5 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(ii) is set forth in Row 6 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iii) is set forth in Row 7 of the cover page for each of the Reporting Persons and is incorporated herein by reference. The information required by Item 4(c)(iv) is set forth in Row 8 of the cover page for each of the Reporting Persons and is incorporated herein by reference. N Y N See Item 2(a). Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Avoro Capital Advisors LLC /s/ Scott Epstein 05/15/2025 Behzad Aghazadeh /s/ Behzad Aghazadeh 05/15/2025