X0306 4 2019-02-20 0 0001576263 Mirati Therapeutics, Inc. MRTX 0001633313 venBio Select Advisor LLC 110 GREENE STREET SUITE 800 NEW YORK NY 10012 0 0 1 0 0001701815 Aghazadeh Behzad 110 GREENE STREET SUITE 800 NEW YORK NY 10012 0 0 1 0 Common Stock, $0.001 par value per share 2019-02-20 4 S 0 686820 73.00 D 4111281 I See footnotes The securities reported herein are held on behalf of accounts managed by venBio Select Advisor LLC, a Delaware limited liability company (the "Investment Manager") and venBio Select Fund LLC, a Delaware limited liability company, a fund managed by the Investment Manager. Behzad Aghazadeh ("Dr. Aghazadeh," and together with the Investment Manager, the "Reporting Persons") serves as the portfolio manager and controlling person of the Investment Manager. The filing of this statement shall not be deemed an admission that either of the Reporting Persons is the beneficial owner of the securities reported herein for purposes of Section 16 of the Securities Act of 1934, as amended, or otherwise. Each of the Reporting Persons expressly disclaims beneficial ownership of the securities reported herein except to the extent of its or his pecuniary interest therein. venBio Select Advisor LLC, by: /s/ Scott Epstein, its Chief Financial Officer & Chief Compliance Officer 2019-02-21 /s/ Behzad Aghazadeh 2019-02-21