The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
NOVO-NORDISK A S ADR 670100205 20,190 419,324 SH   SOLE   419,324 0 0
ABBOTT LABS COM 002824100 34 639 SH   SOLE   639 0 0
ABBVIE INC COM 00287Y109 43 489 SH   SOLE   489 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 1,249 8,905 SH   SOLE   8,905 0 0
ALLEGHANY CORP DEL COM 017175100 423 764 SH   SOLE   764 0 0
ALPHABET INC CAP STK CL A 02079K305 7,920 8,134 SH   SOLE   8,134 0 0
ALPHABET INC CAP STK CL C 02079K107 19,784 20,627 SH   SOLE   20,627 0 0
AQUABOUNTY TECHNOLOGIES INC COM NEW 03842K200 14 1,987 SH   SOLE   1,987 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208 31 850 SH   SOLE   850 0 0
BERKSHIRE HATHAWAY INC DEL CL A 084670108 549 2 SH   SOLE   2 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 391 2,135 SH   SOLE   2,135 0 0
BROWN FORMAN CORP CL B 115637209 226 4,158 SH   SOLE   4,158 0 0
CIMAREX ENERGY CO COM 171798101 21,279 187,200 SH   SOLE   187,200 0 0
COCA COLA CO COM 191216100 164 3,650 SH   SOLE   3,650 0 0
CONOCOPHILLIPS COM 20825C104 56 1,115 SH   SOLE   1,115 0 0
DIGIMARC CORP NEW COM 25381B101 25,155 687,296 SH   SOLE   687,296 0 0
ENSTAR GROUP LIMITED SHS G3075P101 6,544 29,432 SH   SOLE   29,432 0 0
EXXON MOBIL CORP COM 30231G102 145 1,765 SH   SOLE   1,765 0 0
INTREXON CORP COM 46122T102 3,422 180,007 SH   SOLE   180,007 0 0
JOHNSON & JOHNSON COM 478160104 78 600 SH   SOLE   600 0 0
LAS VEGAS SANDS CORP COM 517834107 67 1,050 SH   SOLE   1,050 0 0
MASTERCARD INCORPORATED CL A 57636Q104 222 1,573 SH   SOLE   1,573 0 0
MICROSOFT CORP COM 594918104 402 5,400 SH   SOLE   5,400 0 0
MONSANTO CO NEW COM 61166W101 4,103 34,241 SH   SOLE   34,241 0 0
PFIZER INC COM 717081103 44 1,226 SH   SOLE   1,226 0 0
PHILLIPS 66 COM 718546104 18 197 SH   SOLE   197 0 0
PRICELINE GRP INC COM NEW 741503403 16,384 8,949 SH   SOLE   8,949 0 0
PROCTER AND GAMBLE CO COM 742718109 63 690 SH   SOLE   690 0 0
PTC INC COM 69370C100 7,600 135,038 SH   SOLE   135,038 0 0
REGENERON PHARMACEUTICALS COM 75886F107 24,912 55,717 SH   SOLE   55,717 0 0
RENAISSANCERE HOLDINGS LTD COM G7496G103 20,148 149,087 SH   SOLE   149,087 0 0
SEATTLE GENETICS INC COM 812578102 16,687 306,694 SH   SOLE   306,694 0 0
SENOMYX INC COM 81724Q107 898 1,481,024 SH   SOLE   1,481,024 0 0
SPDR GOLD TRUST GOLD SHS 78463V107 109 900 SH   SOLE   900 0 0
T2 BIOSYSTEMS INC COM 89853L104 13,392 3,188,539 SH   SOLE   3,188,539 0 0
TESLA INC COM 88160R101 6,651 19,498 SH   SOLE   19,498 0 0
TEXAS PAC LD TR SUB CTF PROP I T 882610108 8,054 19,930 SH   SOLE   19,930 0 0
TRUPANION INC COM 898202106 5,022 190,162 SH   SOLE   190,162 0 0
UBIQUITI NETWORKS INC COM 90347A100 24,709 441,077 SH   SOLE   441,077 0 0
VOLITIONRX LTD COM 928661107 8,828 3,356,754 SH   SOLE   3,356,754 0 0
WD-40 CO COM 929236107 7,610 68,005 SH   SOLE   68,005 0 0
XPO LOGISTICS INC COM 983793100 3,059 45,135 SH   SOLE   45,135 0 0