The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| GLAXOSMITHKLINE PLC | SPONSORED ADR | 37733W105 | 9 | 239 | SH | SOLE | 239 | 0 | 0 | ||
| NIDEC CORP | SPONSORED ADR | 654090109 | 1,342 | 77,428 | SH | SOLE | 77,428 | 0 | 0 | ||
| NOVO-NORDISK A S | ADR | 670100205 | 36,488 | 672,721 | SH | SOLE | 672,721 | 0 | 0 | ||
| RANDGOLD RES LTD | ADR | 752344309 | 266 | 4,500 | SH | SOLE | 4,500 | 0 | 0 | ||
| ALPHABET INC F/K/A GOOGLE INC | CL A | 02079K305 | 8,271 | 12,956 | SH | SOLE | 12,956 | 0 | 0 | ||
| ALPHABET INC F/K/A GOOGLE INC | CL C | 02079K107 | 16,876 | 27,738 | SH | SOLE | 27,738 | 0 | 0 | ||
| ABBOTT LABS | COM | 002824100 | 26 | 640 | SH | SOLE | 640 | 0 | 0 | ||
| ABBVIE INC | COM | 00287Y109 | 27 | 491 | SH | SOLE | 491 | 0 | 0 | ||
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 26,104 | 166,914 | SH | SOLE | 166,914 | 0 | 0 | ||
| ALLEGHANY CORP DEL | COM | 017175100 | 300 | 640 | SH | SOLE | 640 | 0 | 0 | ||
| ALLISON TRANSMISSION HLDGS I | COM | 01973R101 | 9,264 | 347,083 | SH | SOLE | 347,083 | 0 | 0 | ||
| BERKSHIRE HATHAWAY INC DEL | CL A | 084670108 | 22,257 | 114 | SH | SOLE | 114 | 0 | 0 | ||
| BERKSHIRE HATHAWAY INC DEL | CL B NEW | 084670702 | 4,565 | 35,011 | SH | SOLE | 35,011 | 0 | 0 | ||
| CONOCOPHILLIPS | COM | 20825C104 | 81 | 1,699 | SH | SOLE | 1,699 | 0 | 0 | ||
| CORNING INC | COM | 219350105 | 10,920 | 637,846 | SH | SOLE | 637,846 | 0 | 0 | ||
| DIGIMARC CORP NEW | COM | 25381B101 | 11,740 | 384,304 | SH | SOLE | 384,304 | 0 | 0 | ||
| ENSTAR GROUP LIMITED | SHS | G3075P101 | 3,794 | 25,294 | SH | SOLE | 25,294 | 0 | 0 | ||
| EXXON MOBIL CORP | COM | 30231G102 | 53 | 715 | SH | SOLE | 715 | 0 | 0 | ||
| INTREXON CORP | COM | 46122T102 | 13,279 | 417,569 | SH | SOLE | 417,569 | 0 | 0 | ||
| JOHNSON & JOHNSON | COM | 478160104 | 7,073 | 75,765 | SH | SOLE | 75,765 | 0 | 0 | ||
| MASTERCARD INC | CL A | 57636Q104 | 3,036 | 33,690 | SH | SOLE | 33,690 | 0 | 0 | ||
| MERRIMACK PHARMACEUTICALS IN | COM | 590328100 | 20,063 | 2,357,558 | SH | SOLE | 2,357,558 | 0 | 0 | ||
| MONSANTO CO NEW | COM | 61166W101 | 15,113 | 177,090 | SH | SOLE | 177,090 | 0 | 0 | ||
| PFIZER INC | COM | 717081103 | 51 | 1,617 | SH | SOLE | 1,617 | 0 | 0 | ||
| PHILLIPS 66 | COM | 718546104 | 19 | 247 | SH | SOLE | 247 | 0 | 0 | ||
| PTC INC | COM | 69370C100 | 9,957 | 313,701 | SH | SOLE | 313,701 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 46,397 | 99,748 | SH | SOLE | 99,748 | 0 | 0 | ||
| RENAISSANCERE HOLDINGS LTD | COM | G7496G103 | 23,049 | 216,790 | SH | SOLE | 216,790 | 0 | 0 | ||
| SEATTLE GENETICS INC | COM | 812578102 | 24,552 | 636,730 | SH | SOLE | 636,730 | 0 | 0 | ||
| SENOMYX INC | COM | 81724Q107 | 18,761 | 4,206,491 | SH | SOLE | 4,206,491 | 0 | 0 | ||
| UBIQUITI NETWORKS INC | COM | 90347A100 | 4,588 | 135,375 | SH | SOLE | 135,375 | 0 | 0 | ||
| VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 4,286 | 24,025 | SH | SOLE | 24,025 | 0 | 0 | ||