X0306 4 2018-05-22 0 0001631650 Aimmune Therapeutics, Inc. AIMT 0001488637 Sheehy Douglas T. AIMMUNE THERAPEUTICS, INC. 8000 MARINA BOULEVARD, SUITE 300 BRISBANE CA 94005-1884 0 1 0 0 See Remarks Common Stock, $0.0001 par value 2018-05-22 4 M 0 1648 12.95 A 34727 D Common Stock, $0.0001 par value 2018-05-22 4 S 0 1648 33.00 D 33079 D Common Stock, $0.0001 par value 2018-05-22 4 M 0 1648 12.95 A 34727 D Common Stock, $0.0001 par value 2018-05-22 4 S 0 1648 33.00 D 33079 D Stock Option (right to buy) 12.95 2018-05-22 4 M 0 1648 0.00 D 2026-04-29 Common Stock 1648 65297 D Stock Option (right to buy) 12.95 2018-05-22 4 M 0 1648 0.00 D 2026-04-29 Common Stock 1648 63649 D Includes 32,500 shares represented by restricted stock units ("RSUs") and will be settled in common stock upon vesting. The RSUs vest in four successive, equal, annual installments measured from March 1, 2018, subject to the Reporting Person's continued service relationship with the Issuer on each such vesting date. Includes 579 shares acquired on May 15, 2018 pursuant to Issuer's employee stock purchase plan. This sale reported in the Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by Reporting Person. The shares subject to the option will vest and become exercisable as to 25% of the total number of shares subject to the option on April 4, 2017 and with respect to 1/48th of the total number of shares subject to the option in successive, equal monthly installments on each monthly anniversary thereafter, subject to the Reporting Person's continued service relationship with the Issuer on each such vesting date. General Counsel and Corporate Secretary /s/ Douglas T. Sheehy 2018-05-24