X0306 4 2016-11-11 0 0001631650 Aimmune Therapeutics, Inc. AIMT 0001664251 Barrowcliffe Susan E. AIMMUNE THERAPEUTICS, INC. 8000 MARINA BOULEVARD, SUITE 300 BRISBANE CA 94005-1884 0 1 0 0 General Manager, Europe Common Stock, $0.0001 par value 2016-11-11 4 M 0 20000 3.022 A 20000 D Common Stock, $0.0001 par value 2016-11-11 4 S 0 20000 25.00 D 0 D Stock Option (right to buy) 3.022 2016-11-11 4 M 0 20000 0.00 D 2025-05-13 Common Stock 20000 228400 D The sale reported in the Form 4 was effected pursuant to a Rule 10b5 1 trading plan adopted by the Reporting Person. The option is immediately exercisable in full or in part. The underlying shares vest pursuant to the following schedule: Twenty Five Percent (25%) of the shares subject to the option vest on the first anniversary measured from May 1, 2015 (the "Vesting Commencement Date") and the remaining shares subject to the option vest in 36 successive, equal monthly installments thereafter on each monthly anniversary of the Vesting Commencement Date, subject to Reporting Person's continued service relationship with the Issuer on each such vesting date. /s/ Warren L. DeSouza, as Attorney-in-Fact for Susan E. Barrowcliffe 2016-11-15