The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALECTOR INC COM 014442107 11,020 639,569 SH   DFND   639,569 0 0
APTINYX INC COM 03836N103 11,252 3,290,079 SH   DFND   3,290,079 0 0
ARAVIVE INC COM 03890D108 12,938 946,423 SH   DFND   946,423 0 0
ARVINAS INC COM 04335A105 93,810 2,283,048 SH   DFND   2,283,048 0 0
AVROBIO INC COM 05455M100 6,352 315,550 SH   DFND   315,550 0 0
CHIASMA INC COM 16706W102 3,649 735,700 SH   DFND   735,700 0 0
CHIMERIX INC COM 16934W106 2,741 1,350,000 SH   DFND   1,350,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 3,538 141,000 SH   DFND   141,000 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 129,878 2,086,723 SH   DFND   2,086,723 0 0
HARPOON THERAPEUTICS INC COM 41358P106 43,208 2,921,405 SH   DFND   2,921,405 0 0
ITERUM THERAPEUTICS PLC SHS G6333L101 6,553 1,456,303 SH   DFND   1,456,303 0 0
MINERVA NEUROSCIENCES INC COM 603380106 3,196 449,500 SH   DFND   449,500 0 0
NEURONETICS INC COM 64131A105 4,666 1,039,285 SH   DFND   1,039,285 0 0
OBSEVA SA COM H5861P103 3,440 900,501 SH   DFND   900,501 0 0
PDS BIOTECHNOLOGY CORP COM 70465T107 311 117,242 SH   DFND   117,242 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 50,103 914,625 SH   DFND   914,625 0 0
SIERRA ONCOLOGY INC COM 82640U107 68,760 5,020,446 SH   DFND   5,020,446 0 0
UNUM THERAPEUTICS INC COM 903214104 1,293 1,795,545 SH   DFND   1,795,545 0 0
X4 PHARMACEUTICALS INC COM 98420X103 3,585 335,000 SH   DFND   335,000 0 0