The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AFFIMED N V | COM | N01045108 | 4,163 | 2,250,000 | SH | DFND | 2,250,000 | 0 | 0 | ||
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 2,797 | 964,520 | SH | DFND | 964,520 | 0 | 0 | ||
| CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 27,227 | 595,642 | SH | DFND | 595,642 | 0 | 0 | ||
| DECIPHERA PHARMACEUTICALS INC | COM | 24344T101 | 82,247 | 4,104,140 | SH | DFND | 4,104,140 | 0 | 0 | ||
| DERMIRA INC | COM | 24983L104 | 488 | 61,109 | SH | DFND | 61,109 | 0 | 0 | ||
| EDGE THERAPEUTICS INC | COM | 279870109 | 2,767 | 2,344,868 | SH | DFND | 2,344,868 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 1,309 | 342,550 | SH | DFND | 342,550 | 0 | 0 | ||
| OBSEVA SA | COM | H5861P103 | 12,017 | 890,501 | SH | DFND | 890,501 | 0 | 0 | ||
| OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 10,614 | 852,497 | SH | DFND | 852,497 | 0 | 0 | ||
| RESHAPE LIFESCIENCES INC | COM | 761123108 | 3,771 | 2,600,900 | SH | DFND | 2,600,900 | 0 | 0 | ||
| SIERRA ONCOLOGY INC | COM | 82640U107 | 10,392 | 5,020,446 | SH | DFND | 5,020,446 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 2,910 | 404,159 | SH | DFND | 404,159 | 0 | 0 | ||
| UNUM THERAPEUTICS INC | COM | 903214104 | 6,111 | 550,000 | SH | DFND | 550,000 | 0 | 0 | ||
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 18,376 | 458,259 | SH | DFND | 458,259 | 0 | 0 | ||