The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ALDER BIOPHARMACEUTICALS INC COM 014339105 1,962 171,364 SH   DFND   171,364 0 0
AVEO PHARMACEUTICALS INC COM 053588109 2,691 964,520 SH   DFND   964,520 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 11,922 507,730 SH   DFND   507,730 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 93,041 4,104,140 SH   DFND   4,104,140 0 0
DERMIRA INC COM 24983L104 1,699 61,109 SH   DFND   61,109 0 0
EDGE THERAPEUTICS INC COM 279870109 21,971 2,344,868 SH   DFND   2,344,868 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 18,426 328,741 SH   DFND   328,741 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 3,468 425,000 SH   DFND   425,000 0 0
OBSEVA SA COM H5861P103 8,691 890,501 SH   DFND   890,501 0 0
OTONOMY INC COM 68906L105 610 109,825 SH   DFND   109,825 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 11,909 852,497 SH   DFND   852,497 0 0
RESHAPE LIFESCIENCES INC COM 761123108 3,849 2,600,900 SH   DFND   2,600,900 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,118 25,000 SH   DFND   25,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 10,437 2,798,224 SH   DFND   2,798,224 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 2,930 404,159 SH   DFND   404,159 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 16,085 458,259 SH   DFND   458,259 0 0