Unaudited Consolidated Statements of Series A Preferred Shares and Shareholders' Equity (Deficit) - USD ($) $ in Thousands	Total	GSK Collaboration Agreement [Member]	At-The-Market Equity Program [Member]	Series A Preferred Shares [Member]	Ordinary Shares [Member]	Ordinary Shares [Member] GSK Collaboration Agreement [Member]	Ordinary Shares [Member] At-The-Market Equity Program [Member]	Additional Paid-In-Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2022	$ (45,091)				$ 802,833			$ 119,442	$ (29)	$ (967,337)
Beginning balance, shares at Dec. 31, 2022					86,924,643
Temporary equity, Beginning balance at Dec. 31, 2022				$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2022				3,901,348
Issuance of ordinary shares		$ 34,623				$ 34,623
Issuance of ordinary shares, shares						10,683,761
Share-based compensation	2,750							2,750
Vesting of RSUs, shares					363,161
Option exercises	1				$ 1
Option exercises, shares					181
Issuance of ordinary shares under the ESPP	429				$ 429
Issuance of ordinary shares under ESPP, shares					133,098
Other comprehensive loss	(21)								(21)
Net loss	(27,405)									(27,405)
Ending balance at Mar. 31, 2023	(34,714)				$ 837,886			122,192	(50)	(994,742)
Ending balance, shares at Mar. 31, 2023					98,104,844
Temporary equity, Ending balance at Mar. 31, 2023				$ 7,874
Temporary equity, Ending balance, shares at Mar. 31, 2023				3,901,348
Beginning balance at Dec. 31, 2022	(45,091)				$ 802,833			119,442	(29)	(967,337)
Beginning balance, shares at Dec. 31, 2022					86,924,643
Temporary equity, Beginning balance at Dec. 31, 2022				$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2022				3,901,348
Net loss	(48,509)
Ending balance at Jun. 30, 2023	(51,720)				$ 839,675			124,601	(150)	(1,015,846)
Ending balance, shares at Jun. 30, 2023					98,566,816
Temporary equity, Ending balance at Jun. 30, 2023				$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2023				3,901,348
Beginning balance at Mar. 31, 2023	(34,714)				$ 837,886			122,192	(50)	(994,742)
Beginning balance, shares at Mar. 31, 2023					98,104,844
Temporary equity, Beginning balance at Mar. 31, 2023				$ 7,874
Temporary equity, Beginning balance, shares at Mar. 31, 2023				3,901,348
Issuance of ordinary shares			$ 1,704				$ 1,704
Issuance of ordinary shares, shares							429,051
Share-based compensation	2,409							2,409
Vesting of RSUs, shares					9,234
Option exercises	85				$ 85
Option exercises, shares					23,687
Other comprehensive loss	(100)								(100)
Net loss	(21,104)									(21,104)
Ending balance at Jun. 30, 2023	(51,720)				$ 839,675			124,601	(150)	(1,015,846)
Ending balance, shares at Jun. 30, 2023					98,566,816
Temporary equity, Ending balance at Jun. 30, 2023				$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2023				3,901,348
Beginning balance at Dec. 31, 2023	39,630				$ 935,367			129,237	(124)	(1,024,850)
Beginning balance, shares at Dec. 31, 2023					119,162,234
Temporary equity, Beginning balance at Dec. 31, 2023	$ 7,874			$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2023	3,901,348			3,901,348
Issuance of ordinary shares	$ 14,038				$ 14,038
Issuance of ordinary shares, shares					3,000,000
Share-based compensation	2,881							2,881
Vesting of RSUs, shares					21,683
Option exercises	123				$ 123
Option exercises, shares					35,925
Issuance of ordinary shares under the ESPP	349				$ 349
Issuance of ordinary shares under ESPP, shares					101,542
Other comprehensive loss	(74)								(74)
Net loss	(31,558)									(31,558)
Ending balance at Mar. 31, 2024	25,389				$ 949,877			132,118	(198)	(1,056,408)
Ending balance, shares at Mar. 31, 2024					122,321,384
Temporary equity, Ending balance at Mar. 31, 2024				$ 7,874
Temporary equity, Ending balance, shares at Mar. 31, 2024				3,901,348
Beginning balance at Dec. 31, 2023	39,630				$ 935,367			129,237	(124)	(1,024,850)
Beginning balance, shares at Dec. 31, 2023					119,162,234
Temporary equity, Beginning balance at Dec. 31, 2023	$ 7,874			$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2023	3,901,348			3,901,348
Net loss	$ (64,481)
Ending balance at Jun. 30, 2024	(3,477)				$ 950,530			135,603	(279)	(1,089,331)
Ending balance, shares at Jun. 30, 2024					122,479,289
Temporary equity, Ending balance at Jun. 30, 2024	$ 7,874			$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2024	3,901,348			3,901,348
Beginning balance at Mar. 31, 2024	$ 25,389				$ 949,877			132,118	(198)	(1,056,408)
Beginning balance, shares at Mar. 31, 2024					122,321,384
Temporary equity, Beginning balance at Mar. 31, 2024				$ 7,874
Temporary equity, Beginning balance, shares at Mar. 31, 2024				3,901,348
Issuance of ordinary shares			$ 547				$ 547
Issuance of ordinary shares, shares							109,204
Share-based compensation	3,485							3,485
Vesting of RSUs, shares					17,778
Option exercises	106				$ 106
Option exercises, shares					30,923
Other comprehensive loss	(81)								(81)
Net loss	(32,923)									(32,923)
Ending balance at Jun. 30, 2024	(3,477)				$ 950,530			$ 135,603	$ (279)	$ (1,089,331)
Ending balance, shares at Jun. 30, 2024					122,479,289
Temporary equity, Ending balance at Jun. 30, 2024	$ 7,874			$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2024	3,901,348			3,901,348