Unaudited Consolidated Statements of Cash Flows - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities
Net loss	$ (79,110)	$ (81,230)
Adjustments to reconcile net loss to net cash used in operating activities:
Amortization of right-of-use assets	1,593	1,043
Depreciation of property and equipment	3,425	3,857
Share-based compensation expense	10,921	6,785
Changes in operating assets and liabilities:
Accounts receivable		30,000
Prepaid expenses	1,188	1,246
Other assets	(1,946)	(3,475)
Accounts payable	3,264	(5,251)
Accrued expenses and other current liabilities	(3,776)	(2,048)
Deferred revenue	(1,855)	(2,776)
Operating lease liabilities	(2,399)	(1,792)
Other non-current liabilities	0	(135)
Net cash used in operating activities	(68,695)	(53,776)
Cash flows from investing activities
Purchases of property and equipment	(700)	(447)
Proceeds from the sale of property and equipment	106
Purchase of short-term investments	(50,000)
Proceeds from the maturity of short-term investments	25,000
Net cash used in investing activities	(25,594)	(447)
Cash flows from financing activities
Proceeds from issuance of ordinary shares, net of offering costs	51,464
Proceeds from issuance pre-funded warrants, net of offering costs	14,336
Proceeds from the exercise of share options	37	200
Proceeds from the ESPP	174	336
Net cash provided by financing activities	67,116	13,686
Effect of foreign exchange rates on cash, cash equivalents and restricted cash	(228)	(120)
Net decrease in cash, cash equivalents and restricted cash	(27,401)	(40,657)
Cash, cash equivalents and restricted cash, beginning of period	154,215	188,148
Cash, cash equivalents and restricted cash, end of period	126,814	147,491
Supplemental disclosure of cash flow information:
Increase in operating lease right-of-use assets and lease liabilities related to lease extension	12,006
Offering costs in accounts payable at period end	311	57
At-The-Market Equity Program [Member]
Cash flows from financing activities
Proceeds from issuance of ordinary shares, net of offering costs	$ 1,105	$ 13,150