Unaudited Consolidated Statements of Series A Preferred Shares and Shareholders' Equity (Deficit) - USD ($) $ in Thousands	Total	At-The-Market Equity Program [Member]	Series A Preferred Shares [Member]	Ordinary Shares [Member]	Ordinary Shares [Member] At-The-Market Equity Program [Member]	Additional Paid-In-Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2020	$ 82,778			$ 694,085		$ 71,573	$ 389	$ (683,269)
Beginning balance, shares at Dec. 31, 2020				48,778,678
Temporary equity, Beginning balance at Dec. 31, 2020			$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2020			3,901,348
Issuance of ordinary shares		$ 8,028			$ 8,028
Issuance of ordinary shares, shares					844,796
Share-based compensation	4,063					4,063
Vesting of RSUs, shares				155,184
Option exercises	200			$ 200
Option exercises, shares				31,957
Issuance of ordinary shares under the ESPP	336			$ 336
Issuance of ordinary shares under ESPP, shares				44,036
Other comprehensive loss	(120)						(120)
Net loss	(42,464)							(42,464)
Ending balance at Mar. 31, 2021	52,821			$ 702,649		75,636	269	(725,733)
Ending balance, shares at Mar. 31, 2021				49,854,651
Temporary equity, Ending balance at Mar. 31, 2021			$ 7,874
Temporary equity, Ending balance, shares at Mar. 31, 2021			3,901,348
Beginning balance at Dec. 31, 2020	82,778			$ 694,085		71,573	389	(683,269)
Beginning balance, shares at Dec. 31, 2020				48,778,678
Temporary equity, Beginning balance at Dec. 31, 2020			$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2020			3,901,348
Net loss	(81,230)
Ending balance at Jun. 30, 2021	21,842			$ 707,714		78,358	269	(764,499)
Ending balance, shares at Jun. 30, 2021				50,576,466
Temporary equity, Ending balance at Jun. 30, 2021			$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2021			3,901,348
Beginning balance at Mar. 31, 2021	52,821			$ 702,649		75,636	269	(725,733)
Beginning balance, shares at Mar. 31, 2021				49,854,651
Temporary equity, Beginning balance at Mar. 31, 2021			$ 7,874
Temporary equity, Beginning balance, shares at Mar. 31, 2021			3,901,348
Issuance of ordinary shares		5,065			$ 5,065
Issuance of ordinary shares, shares					718,179
Share-based compensation	2,722					2,722
Vesting of RSUs, shares				3,636
Net loss	(38,766)							(38,766)
Ending balance at Jun. 30, 2021	21,842			$ 707,714		78,358	269	(764,499)
Ending balance, shares at Jun. 30, 2021				50,576,466
Temporary equity, Ending balance at Jun. 30, 2021			$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2021			3,901,348
Beginning balance at Dec. 31, 2021	32,498			$ 749,851		87,980	181	(805,514)
Beginning balance, shares at Dec. 31, 2021				59,841,116
Temporary equity, Beginning balance at Dec. 31, 2021	$ 7,874		$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2021	3,901,348		3,901,348
Issuance of ordinary shares		$ 1,167			$ 1,167
Issuance of ordinary shares, shares					458,092
Share-based compensation	$ 3,971					3,971
Vesting of RSUs, shares				468,226
Option exercises	37			$ 37
Option exercises, shares				15,000
Issuance of ordinary shares under the ESPP	174			$ 174
Issuance of ordinary shares under ESPP, shares				77,534
Other comprehensive loss	(86)						(86)
Net loss	(37,814)							(37,814)
Ending balance at Mar. 31, 2022	(53)			$ 751,229		91,951	95	(843,328)
Ending balance, shares at Mar. 31, 2022				60,859,968
Temporary equity, Ending balance at Mar. 31, 2022			$ 7,874
Temporary equity, Ending balance, shares at Mar. 31, 2022			3,901,348
Beginning balance at Dec. 31, 2021	32,498			$ 749,851		87,980	181	(805,514)
Beginning balance, shares at Dec. 31, 2021				59,841,116
Temporary equity, Beginning balance at Dec. 31, 2021	$ 7,874		$ 7,874
Temporary equity, Beginning balance, shares at Dec. 31, 2021	3,901,348		3,901,348
Net loss	$ (79,110)
Ending balance at Jun. 30, 2022	30,947			$ 802,449		113,169	(47)	(884,624)
Ending balance, shares at Jun. 30, 2022				86,724,658
Temporary equity, Ending balance at Jun. 30, 2022	$ 7,874		$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2022	3,901,348		3,901,348
Beginning balance at Mar. 31, 2022	$ (53)			$ 751,229		91,951	95	(843,328)
Beginning balance, shares at Mar. 31, 2022				60,859,968
Temporary equity, Beginning balance at Mar. 31, 2022			$ 7,874
Temporary equity, Beginning balance, shares at Mar. 31, 2022			3,901,348
Issuance of ordinary shares	51,220			$ 51,220
Issuance of ordinary shares, shares				25,464,483
Issuance of pre-funded warrants , net of offering costs.	14,268					14,268
Share-based compensation	6,950					6,950
Vesting of RSUs, shares				400,207
Other comprehensive loss	(142)						(142)
Net loss	(41,296)							(41,296)
Ending balance at Jun. 30, 2022	30,947			$ 802,449		$ 113,169	$ (47)	$ (884,624)
Ending balance, shares at Jun. 30, 2022				86,724,658
Temporary equity, Ending balance at Jun. 30, 2022	$ 7,874		$ 7,874
Temporary equity, Ending balance, shares at Jun. 30, 2022	3,901,348		3,901,348